MPP7 通过 EGFR/AKT 信号促进乳腺癌细胞的迁移和侵袭。
MPP7 promotes the migration and invasion of breast cancer cells via EGFR/AKT signaling.
机构信息
Department of Basic Medicine and Biomedical Engineering, Foshan Stomatology Hospital, School of Medicine, Foshan University, Foshan, Guangdong Province, China.
出版信息
Cell Biol Int. 2021 May;45(5):948-956. doi: 10.1002/cbin.11538. Epub 2021 Feb 5.
Metastasis is a major cause of breast cancer death. MPP7 is a cell polarity controller highly linked to cell migration; however, the function of MPP7 in breast cancer remains unknown. In this study, we reported that MPP7 expression was upregulated in breast cancer tissues and high MPP7 expression predicted poor survival in patients with breast cancer. Ectopic expression of MPP7 markedly enhanced the migration and invasion in breast cancer cells. In contrast, depletion of MPP7 resulted in impaired cell mobility and metastasis. Moreover, we demonstrated that MPP7 exerted its promotional effect via modulation of EMT and activation of the EGFR/AKT cascade. Our study reveals an oncogenic role of MPP7 in breast cancer and suggests that MPP7 may serve as a potential target for exploring novel therapeutic strategies against breast cancer metastasis.
转移是乳腺癌死亡的主要原因。MPP7 是一种与细胞迁移高度相关的细胞极性控制器；然而，MPP7 在乳腺癌中的功能尚不清楚。在这项研究中，我们报道 MPP7 的表达在乳腺癌组织中上调，并且高 MPP7 表达预示着乳腺癌患者的预后不良。MPP7 的异位表达显著增强了乳腺癌细胞的迁移和侵袭。相比之下，MPP7 的耗竭导致细胞迁移和转移受损。此外，我们证明 MPP7 通过调节 EMT 和激活 EGFR/AKT 级联发挥其促进作用。我们的研究揭示了 MPP7 在乳腺癌中的致癌作用，并表明 MPP7 可能作为探索针对乳腺癌转移的新型治疗策略的潜在靶点。
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