Pang Calver, Fan Ka Siu, Wei Lanxuan, Kolar Mallappa K
Department of Surgical Biotechnology, Division of Surgery & Interventional Science, Faculty of Medical Sciences, University College London, London, United Kingdom.
Faculty of Medicine, St. George's, University of London, London, United Kingdom.
Wound Repair Regen. 2021 Mar;29(2):225-239. doi: 10.1111/wrr.12881. Epub 2020 Dec 30.
Wound healing is a complex and highly regulated process that is susceptible to a variety of failures leading to delayed wound healing or chronic wounds. This is becoming an increasingly global burden on the healthcare system. Treatment of wounds has evolved considerably to overcome barriers to wound healing especially within the field of regenerative medicine that focuses on the replacement of tissues or organs. Improved understanding of the pathophysiology of wound healing has enabled current advances in technology to allow better optimization of microenvironment within wounds. This approach may help tackle wounds that are difficult to treat and help reduce the global burden of the disease. This article provides an overview of the physiology in wound healing and the application of gene therapy using nanotechnology in the management of wounds.
伤口愈合是一个复杂且高度受调控的过程，容易出现各种导致伤口愈合延迟或慢性伤口的失败情况。这正成为医疗保健系统日益沉重的全球负担。伤口治疗已经有了很大的发展，以克服伤口愈合的障碍，特别是在专注于组织或器官替代的再生医学领域。对伤口愈合病理生理学的深入理解使当前的技术进步能够更好地优化伤口内的微环境。这种方法可能有助于解决难以治疗的伤口，并有助于减轻该疾病的全球负担。本文概述了伤口愈合的生理学以及纳米技术在伤口管理中的基因治疗应用。
