School of Chemical Engineering, College of Engineering, University of Tehran, Tehran, Iran.
Skin & Stem cell Research Center, Tehran University of Medical Sciences, Tehran, Iran.
Nanomedicine (Lond). 2017 Oct;12(19):2403-2422. doi: 10.2217/nnm-2017-0173. Epub 2017 Sep 4.
Skin is the outermost covering of the human body and at the same time the largest organ comprising 15% of body weight and 2 m surface area. Skin plays a key role as a barrier against the outer environment depending on its thickness, color and structure, which differ from one site to another. The four major types of problematic wounds include ulcers (diabetic, venous, pressure) and burn wounds. Developing novel dressings helps us to improve the wound healing process in difficult patients. Recent advances in regenerative medicine and nanotechnology are revolutionizing the field of wound healing. Antimicrobial activity, exogenous cell therapy, growth factor delivery, biodegradable and biocompatible matrix construction, all play a role in hi-tech dressing design. In the present review, we discuss how the principles of regenerative medicine and nanotechnology can be combined in innovative wound dressings.
皮肤是人体的最外层覆盖物，同时也是最大的器官，占体重的 15%，面积为 2 平方米。皮肤的厚度、颜色和结构因部位不同而有所差异，其作为人体与外界环境之间的屏障起着关键作用。四大类问题性伤口包括溃疡（糖尿病性、静脉性、压力性）和烧伤伤口。新型敷料的开发有助于改善困难患者的伤口愈合过程。再生医学和纳米技术的最新进展正在彻底改变伤口愈合领域。抗菌活性、外源性细胞治疗、生长因子传递、可生物降解和生物相容的基质构建，都在高科技敷料设计中发挥作用。在本综述中，我们讨论了如何将再生医学和纳米技术的原理结合到创新型伤口敷料中。
