Zhang Ding, Song Dongli, Shi Lin, Sun Xiaoru, Zheng Yonghua, Zeng Yiming, Wang Xiangdong
Zhongshan Hospital Institute of Clinical Science, Zhongshan Hospital, Shanghai Medical College, Fudan University, Shanghai, China.
Department of Pulmonary and Critical Care Medicine, Huashan Hospital, Fudan University, Shanghai, China.
Clin Transl Med. 2020 Dec;10(8):e231. doi: 10.1002/ctm2.231.
Acute lung injury is a serious form and major cause of patient death and still needs efficient therapies. The present study evidenced that co-transplantation of mesenchymal stem cells (MSCs) and telocytes (TCs) improved the severity of experimental lung tissue inflammation, edema, and injury, where TCs increased MSCs migration into the lung and the capacity of MSCs proliferation and movement. Of molecular mechanisms, Osteopontin-dominant networks were active in MSCs and TCs, and might play supportive and nutrimental roles in the interaction between MSCs and TCs, especially activated TCs by lipopolysaccharide. The interaction between epidermal growth factor and its receptor from MSCs and TCs could play critical roles in communications between MSCs and TCs, responsible for MSCs proliferation and movement, especially after inflammatory activation. Our studies provide the evidence that TCs possess nutrimental and supportive roles in implanted MSCs, and co-transplantation of MSCs and TCs can be a new alternative in the therapy of acute lung injury.
急性肺损伤是一种严重的疾病形式，也是患者死亡的主要原因，目前仍需要有效的治疗方法。本研究表明，间充质干细胞（MSCs）和端细胞（TCs）的共移植改善了实验性肺组织炎症、水肿和损伤的严重程度，其中TCs增加了MSCs向肺内的迁移以及MSCs的增殖和移动能力。在分子机制方面，骨桥蛋白主导的网络在MSCs和TCs中活跃，可能在MSCs和TCs的相互作用中发挥支持和营养作用，尤其是脂多糖激活的TCs。MSCs和TCs的表皮生长因子及其受体之间的相互作用可能在MSCs和TCs的通讯中起关键作用，负责MSCs的增殖和移动，尤其是在炎症激活后。我们的研究提供了证据，表明TCs对植入的MSCs具有营养和支持作用，MSCs和TCs的共移植可能成为急性肺损伤治疗的一种新选择。
