Wang Rui, Zhang Tian-Biao, Lü Kun-Long, Zheng Tao, Yin Zheng-Wei, Hao Ya-Wei, Nan Yong-Hao, Zhang Wei-Xing
Department of Andrology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450000, China.
Zhonghua Nan Ke Xue. 2020 Jul;26(7):645-649.
To analyze the blood biochemical characteristics of the ED patients with different types of kidney deficiency or non-kidney deficiency.
We reviewed the clinical data on 156 ED patients treated in our Department of Andrology from May to July 2018 and, according to the traditional Chinese medicine (TCM) syndromes, divided them into four groups: kidney-yang deficiency (n = 48), kidney-yin deficiency (n = 34), kidney-yin+yang deficiency (n = 36) and non-kidney deficiency control (n = 38). We obtained and compared their blood biochemical indexes, including the levels of testosterone (T), estradiol (E2), cortisol (CORT), thyroid stimulating hormone (TSH), free thyroxine (FT4), free triiodothyronine (FT3), nitric oxide (NO), total nitric oxide synthase (tNOS), and inducible nitric oxide synthase (iNOS).
There were no statistically significant differences in the mean age, course of disease, IIEF-5 score and erection hardness score (EHS) among the four groups of patients. Pairwise comparison showed that, compared with the non-kidney deficiency controls, the patients in the kidney-yin deficiency group exhibited a dramatically higher level of CORT (［87.97 ± 45.59］ vs ［121.78 ± 41.87］ μg/L, P = 0.002) and those in the kidney-yang deficiency group a remarkably lower level of FT3 (［5.44 ± 0.38］ vs ［5.11 ± 0.54］ pmol/L, P = 0.008). The iNOS level was significantly higher in the kidney-yin deficiency group (14.42 ± 2.49 U/ml) than in either the control (12.71 ± 2.58 U/ml) (P = 0.039) or the kidney-yang deficiency group (13.05 ± 2.17 U/ml) (P =0.049).
ED patients with different types of kidney deficiency syndromes have different blood biochemical indexes, which may help clarify the biological basis of the TCM syndromes of kidney deficiency in ED patients.
分析不同类型肾虚或非肾虚的勃起功能障碍（ED）患者的血液生化特征。
回顾2018年5月至7月在我院男科治疗的156例ED患者的临床资料，根据中医证候将其分为四组：肾阳虚组（n = 48）、肾阴虚组（n = 34）、肾阴阳两虚组（n = 36）和非肾虚对照组（n = 38）。获取并比较他们的血液生化指标，包括睾酮（T）、雌二醇（E2）、皮质醇（CORT）、促甲状腺激素（TSH）、游离甲状腺素（FT4）、游离三碘甲状腺原氨酸（FT3）、一氧化氮（NO）、总一氧化氮合酶（tNOS）和诱导型一氧化氮合酶（iNOS）水平。
四组患者的平均年龄、病程、国际勃起功能指数-5（IIEF-5）评分和勃起硬度评分（EHS）无统计学显著差异。两两比较显示，与非肾虚对照组相比，肾阴虚组患者的CORT水平显著更高（［87.97 ± 45.59］ vs ［121.78 ± 41.87］ μg/L，P = 0.002），肾阳虚组患者的FT3水平显著更低（［5.44 ± 0.38］ vs ［5.11 ± 0.54］ pmol/L，P = 0.008）。肾阴虚组的iNOS水平显著高于对照组（12.71 ± 2.58 U/ml）（P = 0.039）和肾阳虚组（13.05 ± 2.17 U/ml）（P = 0.049）。
不同类型肾虚证型的ED患者有不同的血液生化指标，这可能有助于阐明ED患者肾虚中医证候的生物学基础。
