Tao Yan, Li Lan-Lan, Liu Shan-Hui, Hong Mei
Research Institute of Urology / Key Laboratory of Urological Diseases of Gansu Province / Nephro-Urological Clinical Center of Gansu Province, Lanzhou University Second Hospital, Lanzhou, Gansu 730030, China.
Zhonghua Nan Ke Xue. 2020 Aug;26(8):745-750.
FOXO3a is an important member of the FOXO subfamily of Forkhead transcription factors, which plays an important role in promoting cell apoptosis, inducing cell cycle arrest, inhibiting cell proliferation and suppressing tumor metastasis through phosphorylation, ubiquitination-mediated degradation and microRNA. Studies show that upregulated expression of FOXO3a can inhibit the growth of PCa cells. This review summarizes the advances in the studies of the FOXO3a signaling pathway in PCa, aiming to provide some new ideas on the clinical diagnosis and targeted therapy of the malignancy.
FOXO3a是叉头转录因子FOXO亚家族的重要成员，它通过磷酸化、泛素化介导的降解和微小RNA在促进细胞凋亡、诱导细胞周期停滞、抑制细胞增殖和抑制肿瘤转移方面发挥重要作用。研究表明，FOXO3a表达上调可抑制前列腺癌细胞的生长。本文综述了前列腺癌中FOXO3a信号通路的研究进展，旨在为该恶性肿瘤的临床诊断和靶向治疗提供一些新思路。
