Department of Endocrinology, Diabetes, and Isotope Therapy, Wroclaw Medical University, Wroclaw, Poland.
Department of Forensic Medicine, Wroclaw Medical University, Wroclaw, Poland.
Endokrynol Pol. 2020;71(6):551-560. doi: 10.5603/EP.a2020.0079.
Thyroid hormones and thyroid-stimulating hormone (TSH) laboratory tests are commonly used worldwide, and their results have an important influence on decisions about treatment and further diagnostic processes. Any discrepancies between symptoms and laboratory results or between results of different tests should be closely investigated to avoid misdiagnosis and unnecessary treatment. Inconsistencies in hormone tests might be a result of physiological changes in hormonal balance, a disease, drug intake, or laboratory interference. Major factors that interfere with thyroid function tests are: heterophilic antibodies, macro TSH, biotin, thyroid hormones autoantibodies, anti-streptavidin, and anti-ruthenium antibodies. In this paper we discuss the influence of different factors on the procedures of hormonal immunoassays, as well as methods to minimise the risk of false results and misdiagnoses.
甲状腺激素和促甲状腺激素（TSH）实验室检测在全球范围内广泛应用，其检测结果对治疗决策和进一步诊断过程具有重要影响。任何症状与实验室结果之间、或不同检测结果之间的差异都应进行深入调查，以避免误诊和不必要的治疗。激素检测结果的不一致可能是由于激素平衡的生理变化、疾病、药物摄入或实验室干扰引起的。干扰甲状腺功能检测的主要因素有：异嗜性抗体、大 TSH、生物素、甲状腺激素自身抗体、抗链亲和素和抗钌抗体。本文讨论了不同因素对激素免疫检测程序的影响，以及如何降低假阳性结果和误诊的风险。
