Department of Pediatric Allergy, Children's Hospital, University of Bonn, Bonn, Germany.
Department of Neonatology and Pediatric Intensive Care, Children's Hospital, University of Bonn, Bonn, Germany.
Pediatr Allergy Immunol. 2021 Jul;32(5):937-944. doi: 10.1111/pai.13444. Epub 2021 Jan 11.
The aim of this study was to investigate the association of serum periostin levels with clinical features in children with asthma.
Children with physician-diagnosed asthma who attended regularly to an outpatient pediatric allergy and asthma center were enrolled in the study along with control subjects. Asthma severity and control status of the patients were evaluated according to the recent GINA guidelines.
A total of 158 children (125 with asthma and 33 age- and sex-matched control subjects) with a median age of 10.2 years (range 5.9-17.0) were enrolled. Asthma severity was mild in 41 (32.8%), moderate in 63 (50.4%), and severe in 21 (16.8%) children. Children with asthma had significantly higher periostin levels than controls (53.1 ± 13.1 vs 43.0 ± 11.2 ng/mL, P < .001). The mean serum periostin levels in children with severe asthma (63.8 ± 10.8) were significantly higher than in children with moderate asthma (53.3 ± 12.7) and mild asthma (47.4 ± 11.1) (P < .001). Results of multivariable logistic regression analysis demonstrated an association between serum periostin levels and asthma severity in children (OR, 1.10; 95% CI, 1.04-1.15, P < .001). When analyzed for the best cut-off value with the highest combined sensitivity and specificity, a cut-off value of 52 ng/mL for serum periostin level was obtained with sensitivity, specificity, PPV, and NPV of 100%, 50%, 29%, and 100%, respectively.
Although serum periostin levels are higher in children with asthma, its diagnostic role in identifying children with severe asthma is limited.
本研究旨在探讨血清骨膜蛋白水平与哮喘患儿临床特征的相关性。
本研究纳入了定期到儿科过敏和哮喘中心就诊、经医生诊断为哮喘的患儿和对照组儿童。根据最近的 GINA 指南评估患者的哮喘严重程度和控制状况。
共纳入 158 名儿童（125 名哮喘患儿和 33 名年龄和性别匹配的对照组儿童），中位年龄为 10.2 岁（范围为 5.9-17.0）。哮喘严重程度为轻度 41 例（32.8%）、中度 63 例（50.4%）、重度 21 例（16.8%）。哮喘患儿的骨膜蛋白水平显著高于对照组（53.1±13.1 vs 43.0±11.2 ng/mL，P<0.001）。重度哮喘患儿的平均血清骨膜蛋白水平（63.8±10.8）显著高于中度哮喘患儿（53.3±12.7）和轻度哮喘患儿（47.4±11.1）（P<0.001）。多变量逻辑回归分析结果表明，血清骨膜蛋白水平与儿童哮喘严重程度之间存在关联（OR，1.10；95%CI，1.04-1.15，P<0.001）。当分析最佳截断值时，血清骨膜蛋白水平的截断值为 52ng/mL，其灵敏度、特异性、PPV 和 NPV 分别为 100%、50%、29%和 100%。
虽然哮喘患儿的血清骨膜蛋白水平较高，但在识别重度哮喘患儿方面的诊断作用有限。
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