Department of Pediatrics, All India Institute of Medical Sciences, Jodhpur, Rajasthan.
Department of Biochemistry, All India Institute of Medical Sciences, Jodhpur, Rajasthan.
Indian Pediatr. 2023 Oct 15;60(10):822-825. Epub 2023 May 30.
To determine the association between serum periostin levels and asthma control in children.
Children aged 6-17 years with physician-diagnosed asthma were enrolled in the study. Age-matched (±2 years) control children, who visited our outpatient department with non-respiratory complaints, were also enrolled.
A total of 90 children (60 with asthma and 30 control subjects) with a mean (SD) age of 12.1 (2.77) years were enrolled. Children with asthma had significantly higher median (IQR) periostin levels than the controls [23.5 (22,26) vs 22 (19.4, 22.96); P= 0.04]. On multivariable logistic regression analysis, serum periostin levels were associated with poor asthma control in children [OR (95% CI), 1.12 (1.01-1.24); P= 0.02]. Age, body mass index, IgE levels, eosinophil count, forced expiratory volume in first minute (FEV1) and presence of allergic rhinitis did not have any association with asthma control.
Asthmatic children have a high serum periostin level, and its higher levels are associated with poor asthma control.
确定血清骨膜蛋白水平与儿童哮喘控制之间的关系。
本研究纳入了年龄在 6-17 岁之间、经医生诊断患有哮喘的儿童。同时，还纳入了年龄匹配（±2 岁）、因非呼吸道疾病就诊的对照组儿童。
共纳入了 90 名儿童（60 名哮喘患儿和 30 名对照组儿童），平均（SD）年龄为 12.1（2.77）岁。哮喘患儿的中位（IQR）骨膜蛋白水平明显高于对照组[23.5（22，26）比 22（19.4，22.96）；P=0.04]。多变量逻辑回归分析显示，血清骨膜蛋白水平与儿童哮喘控制不良相关[比值比（95%置信区间），1.12（1.01-1.24）；P=0.02]。年龄、体重指数、IgE 水平、嗜酸性粒细胞计数、第一秒用力呼气量（FEV1）以及过敏性鼻炎与哮喘控制均无相关性。
哮喘儿童的血清骨膜蛋白水平较高，其较高水平与哮喘控制不良有关。
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