MYC和BCL2表达在43例弥漫性大B细胞淋巴瘤患者队列中的作用：一项回顾性研究。 - Suppr

Role of MYC and BCL2 expression in a cohort of 43 patients with DLBCL: a retrospective study.

作者信息

Khan Umair Tahir, Kelly Michael, Dodd James, Fergiani Sammy, Hammer Barbara, Smith Jeffrey, Arumainathan Arvind, Atherton Mark, Carter Anthony, Racu-Amoasii Igor, Kalakonda Nagesh, Pettitt Andrew, Menon Geetha

机构信息

Molecular & Clinical Cancer Medicine, University of Liverpool, Liverpool, UK

Department of Haematology, Royal Liverpool & Broadgreen University Hospitals NHS Trust, Liverpool, UK.

出版信息

J Clin Pathol. 2021 Dec;74(12):816-818. doi: 10.1136/jclinpath-2020-207121. Epub 2020 Dec 30.

DOI:10.1136/jclinpath-2020-207121

PMID:33380460

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8606458/

Abstract

摘要

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/33a6/8606458/f2f963b9cf42/jclinpath-2020-207121f01.jpg

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Br J Haematol. 2014 May;165(3):382-91. doi: 10.1111/bjh.12763. Epub 2014 Feb 8.

MYC/BCL2 protein coexpression contributes to the inferior survival of activated B-cell subtype of diffuse large B-cell lymphoma and demonstrates high-risk gene expression signatures: a report from The International DLBCL Rituximab-CHOP Consortium Program.MYC/BCL2 蛋白共表达有助于激活 B 细胞型弥漫性大 B 细胞淋巴瘤的生存预后不良，并表现出高危基因表达特征：来自国际弥漫性大 B 细胞淋巴瘤利妥昔单抗-CHOP 联合方案的报告。

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Blood. 2013 Mar 21;121(12):2253-63. doi: 10.1182/blood-2012-06-435842. Epub 2013 Jan 18.

Concurrent expression of MYC and BCL2 in diffuse large B-cell lymphoma treated with rituximab plus cyclophosphamide, doxorubicin, vincristine, and prednisone.利妥昔单抗联合环磷酰胺、多柔比星、长春新碱和泼尼松治疗弥漫性大 B 细胞淋巴瘤时 MYC 和 BCL2 的共表达。

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Structural aberrations affecting the MYC locus indicate a poor prognosis independent of clinical risk factors in diffuse large B-cell lymphomas treated within randomized trials of the German High-Grade Non-Hodgkin's Lymphoma Study Group (DSHNHL).在德国高度恶性非霍奇金淋巴瘤研究组（DSHNHL）的随机试验中接受治疗的弥漫性大B细胞淋巴瘤中，影响MYC基因座的结构畸变表明预后不良，且独立于临床危险因素。

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Role of MYC and BCL2 expression in a cohort of 43 patients with DLBCL: a retrospective study.

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