College of Human Development and Health, National Taipei University of Nursing and Health Sciences, Taipei, Taiwan.
College of Human Development and Health; Department of Exercise and Health Science, National Taipei University of Nursing and Health Sciences, Taipei, Taiwan.
Chin J Physiol. 2020 Nov-Dec;63(6):250-255. doi: 10.4103/CJP.CJP_78_20.
Toll-like receptor 4 (TLR-4), which regulate inflammatory reactions, has become a popular research topic in recent years. This article reviews the latest scientific evidence on the regulation of TLR-4 by regular aerobic exercise training. The literature shows that long-term regular aerobic exercise training can effectively attenuate the expression of TLR-4 in immune cells and regulate its downstream intracellular cascade, including the p38 and PI3K/Akt signaling pathways. This further reduces cytokines secretion by inflammatory cells, which enhances immune system. We consider that the scientific evidence that long-term aerobic exercise training improves the inflammatory response provides a reasonable basis for using aerobic exercise training as a treatment for patients.
Toll 样受体 4（TLR-4），调节炎症反应，近年来已成为热门研究课题。本文综述了关于规律有氧运动训练对 TLR-4 调节的最新科学证据。文献表明，长期规律有氧运动训练可有效抑制免疫细胞 TLR-4 的表达，并调节其下游细胞内级联反应，包括 p38 和 PI3K/Akt 信号通路。这进一步减少了炎症细胞分泌细胞因子，增强了免疫系统。我们认为，长期有氧运动训练改善炎症反应的科学证据为将有氧运动训练作为患者的治疗手段提供了合理依据。
