Department of Neurology, Affiliated Hospital of Zunyi Medical University, Zunyi, China.
Prevention and Health Care, Affiliated Hospital of Zunyi Medical University, Zunyi, China.
Contrast Media Mol Imaging. 2020 Dec 14;2020:8894213. doi: 10.1155/2020/8894213. eCollection 2020.
Epilepsy is a common nervous system disease, which affects about 70 million people all over the world. In 2017, the International League Against Epilepsy (ILAE) considered immune factors as its independent cause, and the concept of autoimmune epilepsy (AE) was widely accepted. Early diagnosis and timely treatment can effectively improve the prognosis of the disease. However, due to the diversity of clinical manifestations, the expensive cost of autoantibody detection, and the increased prevalence in Western China, the difficulty for clinicians in early diagnosis and treatment has increased. Fortunately, convenient and fast imaging examinations are expected to help even more. The imaging manifestations of AE patients were characteristic, especially the combined application of structural and functional neuroimaging, which improved the diagnostic value of imaging. In this paper, several common autoantibodies associated with AE and their structure and function changes in neuroimaging were reviewed to provide help for neurologists to achieve the goal of precision medicine.
癫痫是一种常见的神经系统疾病，全球约有 7000 万人受其影响。2017 年，国际抗癫痫联盟（ILAE）将免疫因素视为其独立病因，并广泛接受自身免疫性癫痫（AE）的概念。早期诊断和及时治疗可以有效改善疾病预后。然而，由于临床表现多样、自身抗体检测费用昂贵，以及中国西部地区发病率增高，临床医生在早期诊断和治疗方面的难度增加。幸运的是，方便快捷的影像学检查有望提供更多帮助。AE 患者的影像学表现具有特征性，特别是结构和功能神经影像学的联合应用，提高了影像学的诊断价值。本文综述了几种与 AE 相关的常见自身抗体及其在神经影像学中的结构和功能变化，以期为神经科医生实现精准医疗的目标提供帮助。
