成纤维细胞生长因子 2（FGF2）、成纤维细胞生长因子受体 3（FGFR3）和纤维连接蛋白 1（FGFBP1）在食管鳞状细胞癌中的表达及预后价值。
The Expression and Prognostic Value of FGF2, FGFR3, and FGFBP1 in Esophageal Squamous Cell Carcinoma.
机构信息
Department of Pathology, First Affiliated Hospital, Xinjiang Medical University, Urumqi, Xinjiang, China.
Department of RICU, First Affiliated Hospital, Xinjiang Medical University, Urumqi, Xinjiang, China.
出版信息
Anal Cell Pathol (Amst). 2020 Dec 11;2020:2872479. doi: 10.1155/2020/2872479. eCollection 2020.
BACKGROUND
Esophageal squamous cell carcinoma was treated by operation and chemoradiotherapy. However, the prognosis of most patients is poor after treatment, and most studies have shown that FGF2 and its receptor (FGFR) are involved in the development of various malignant tumors. FGF2 plays an important role in tumor progression and malignancy. In this study, the immunohistochemistry of FGF2, FGFR3, and FGFBP1 was used to further verify the expression of the three proteins in 172 patients with esophageal squamous cell carcinoma (ESCC) who had not received preoperative chemoradiotherapy and its effect on the prognosis of ESCC.
METHODS
(1) test was used to analyze the relationship between proteins and clinicopathological parameters. Survival analysis was used to investigate the effect of three proteins on prognosis. (2) Paired sample -test was used to analyze the mRNA expression of the three proteins in fresh ESCC tissues and adjacent normal tissues.
RESULTS
FGF2 was correlated with tumor size ( = 0.026), gender ( = 0.047), and lymph metastasis ( = 0.007) in ESCC tissues. The high expression of FGFR3 was associated with tumor differentiation ( = 0.043 and < 0.05), lymph node metastasis ( = 0.078 and < 0.1), and race ( = 0.033 and < 0.05). The high expression of FGFBP1 was significantly associated with the degree of tumor differentiation ( = 0.012), age ( = 0.045), and lymph node metastasis ( = 0.032) of ESCC patients. The expression of FGF2, FGFR3, and FGFBP1-mRNA in ESCC tissues was significantly higher than that in adjacent tissues ( < 0.001, < 0.001, and = 0.001). Patients with high expression of FGF2, FGFBP1, and FGFR3 had poor prognosis. There was a weak positive correlation between FGF2 and FGFBP1, as well as FGFR.
CONCLUSION
The FGF2-FGFR3 axis may promote the progression of esophageal squamous cell carcinoma. The FGF2-FGFR3 axis may be a new direction of targeted therapy for esophageal squamous cell carcinoma. FGF2 and FGFR3 may be used as prognostic markers of esophageal squamous cell carcinoma.
背景
食管癌的治疗方法是手术和放化疗。然而，大多数患者治疗后预后较差，大多数研究表明，FGF2 及其受体（FGFR）参与了各种恶性肿瘤的发生。FGF2 在肿瘤的进展和恶性程度中发挥重要作用。在这项研究中，采用免疫组织化学方法检测 172 例未经术前放化疗的食管鳞癌（ESCC）患者中 FGF2、FGFR3 和 FGFBP1 三种蛋白的表达，并进一步验证其对 ESCC 预后的影响。
方法
（1）采用 检验分析蛋白与临床病理参数的关系。采用生存分析探讨三种蛋白对预后的影响。（2）采用配对样本 t 检验分析三种蛋白在新鲜 ESCC 组织及其相邻正常组织中的 mRNA 表达。
结果
FGF2 在 ESCC 组织中与肿瘤大小（ = 0.026）、性别（ = 0.047）和淋巴转移（ = 0.007）相关。FGFR3 的高表达与肿瘤分化（ = 0.043 和 < 0.05）、淋巴结转移（ = 0.078 和 < 0.1）和种族（ = 0.033 和 < 0.05）有关。FGFBP1 的高表达与 ESCC 患者的肿瘤分化程度（ = 0.012）、年龄（ = 0.045）和淋巴结转移（ = 0.032）显著相关。ESCC 组织中 FGF2、FGFR3 和 FGFBP1-mRNA 的表达明显高于相邻组织（ < 0.001、 < 0.001 和 = 0.001）。FGF2、FGFBP1 和 FGFR3 高表达的患者预后较差。FGF2 与 FGFBP1 以及 FGFR 之间呈弱正相关。
结论
FGF2-FGFR3 轴可能促进食管鳞癌的进展。FGF2-FGFR3 轴可能成为食管鳞癌靶向治疗的新方向。FGF2 和 FGFR3 可作为食管鳞癌的预后标志物。
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