冠状动脉疾病与SIRT1蛋白之间的关系。
The relationship between coronary artery disease and SIRT1 protein.
作者信息
Askin Lutfu, Tibilli Hakan, Tanriverdi Okan, Turkmen Serdar
机构信息
Department of Cardiology, Adiyaman Training and Research Hospital, Adiyaman, Turkey.
出版信息
North Clin Istanb. 2020 Oct 1;7(6):631-635. doi: 10.14744/nci.2020.31391. eCollection 2020.
Endothelial cell dysfunction proceeding with increased inflammation and monocyte increase is one of the main causes of vessel injury in CAD. SIRT1 (Sirtuin 1) protein plays an important role in the regulation of cellular physiological mechanisms. SIRT1 has roles in regulating angiogenesis and preventing endothelial dysfunction and reperfusion injury due to ischemia. Suppression of SIRT1 causes monocyte affinity due to endothelial dysfunction. Sirtuins activators are involved in pathologies of many diseases with promising treatments. The objective of this review is to summarize the current progress and future directions of sirtuin protein in the field of CAD.
内皮细胞功能障碍伴炎症增加和单核细胞增多是冠心病血管损伤的主要原因之一。SIRT1（沉默调节蛋白1）蛋白在细胞生理机制调节中起重要作用。SIRT1在调节血管生成以及预防缺血引起的内皮功能障碍和再灌注损伤方面发挥作用。SIRT1的抑制会因内皮功能障碍导致单核细胞亲和力增加。沉默调节蛋白激活剂参与许多疾病的病理过程，有望带来治疗方法。本综述的目的是总结沉默调节蛋白在冠心病领域的当前进展和未来方向。
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