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TBX4 Transcription Factor Is a Positive Feedback Regulator of Itself and Phospho-SMAD1/5.
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Smad1 and Smad5 differentially regulate embryonic hematopoiesis.
Blood. 2007 Dec 1;110(12):3881-90. doi: 10.1182/blood-2007-04-085753. Epub 2007 Aug 29.
3
Transcriptional factors smad1 and smad9 act redundantly to mediate zebrafish ventral specification downstream of smad5.
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Smad1/Smad5 signaling in limb ectoderm functions redundantly and is required for interdigital programmed cell death.
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Smad1/5 is required for erythropoietin-mediated suppression of hepcidin in mice.
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Iron regulation of hepcidin despite attenuated Smad1,5,8 signaling in mice without transferrin receptor 2 or Hfe.
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Changes in Smad1/5/9 expression and phosphorylation in astrocytes of the rat hippocampus after transient global cerebral ischemia.
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Stalk cell phenotype depends on integration of Notch and Smad1/5 signaling cascades.
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Specific control of BMP signaling and mesenchymal differentiation by cytoplasmic phosphatase PPM1H.
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Tbx20 interacts with smads to confine tbx2 expression to the atrioventricular canal.
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Tumors and their microenvironments: Learning from pediatric brain pathologies.
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Unique Pulmonary Hypertensive Vascular Diseases Associated with Heart and Lung Developmental Defects.
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Defining the clinical validity of genes reported to cause pulmonary arterial hypertension.
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An intronic variant in TBX4 in a single family with variable and severe pulmonary manifestations.
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Molecular genetics of pulmonary hypertension in children.
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本文引用的文献

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Phenotype characterisation of mutation and deletion carriers with neonatal and paediatric pulmonary hypertension.
Eur Respir J. 2019 Aug 22;54(2). doi: 10.1183/13993003.01965-2018. Print 2019 Aug.
2
TGFβ and BMPRII signalling pathways in the pathogenesis of pulmonary arterial hypertension.
Drug Discov Today. 2019 Mar;24(3):703-716. doi: 10.1016/j.drudis.2018.12.001. Epub 2018 Dec 7.
3
Exome Sequencing in Children With Pulmonary Arterial Hypertension Demonstrates Differences Compared With Adults.
Circ Genom Precis Med. 2018 Apr;11(4):e001887. doi: 10.1161/CIRCGEN.117.001887.
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Genetics of Pulmonary Arterial Hypertension.
Semin Respir Crit Care Med. 2017 Oct;38(5):585-595. doi: 10.1055/s-0037-1606201. Epub 2017 Oct 15.
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A systematic review of genetic mutations in pulmonary arterial hypertension.
BMC Med Genet. 2017 Aug 2;18(1):82. doi: 10.1186/s12881-017-0440-5.
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Genetic analyses in a cohort of children with pulmonary hypertension.
Eur Respir J. 2016 Oct;48(4):1118-1126. doi: 10.1183/13993003.00211-2016. Epub 2016 Sep 1.
7
Transcription factor TBX4 regulates myofibroblast accumulation and lung fibrosis.
J Clin Invest. 2016 Aug 1;126(8):3063-79. doi: 10.1172/JCI85328. Epub 2016 Jul 11.
8
The Cardiac TBX5 Interactome Reveals a Chromatin Remodeling Network Essential for Cardiac Septation.
Dev Cell. 2016 Feb 8;36(3):262-75. doi: 10.1016/j.devcel.2016.01.009.
9
Multiple roles and interactions of Tbx4 and Tbx5 in development of the respiratory system.
PLoS Genet. 2012;8(8):e1002866. doi: 10.1371/journal.pgen.1002866. Epub 2012 Aug 2.
10
ChIP-seq reveals cell type-specific binding patterns of BMP-specific Smads and a novel binding motif.
Nucleic Acids Res. 2011 Nov 1;39(20):8712-27. doi: 10.1093/nar/gkr572. Epub 2011 Jul 15.

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