磷脂酰丝氨酸在体内可增加大鼠突触体对外源性γ-氨基丁酸（GABA）的摄取。
Phosphatidylserine increases in vivo the synaptosomal uptake of exogenous GABA in rats.
作者信息
Loeb C, Marinari U M, Benassi E, Besio G, Cottalasso D, Cupello A, Maffini M, Mainardi P, Pronzato M A, Scotto P A
机构信息
Institute of Neurology, University of Genova, Italy.
出版信息
Exp Neurol. 1988 Feb;99(2):440-6. doi: 10.1016/0014-4886(88)90160-4.
A sonicated liposome suspension of gamma-aminobutyric acid (GABA) and phosphatidylserine (liposome-entrapped GABA), intraperitoneally administered in rats, inhibited EEG epileptic activity induced by penicillin, whereas GABA did not. A significant increase (20.4%) in brain radioactivity accumulation occurred at 5 min after i.p. administration of [14C]GABA associated with phosphatidylserine in comparison with the administration of [14C]GABA; such an increase persisted after 20 min. However, the accumulation of radioactivity into brain synaptosomes demonstrated a 24.1% increase at 5 min and subsequently showed a 43.3% increase at 20 min after injection of liposome-entrapped GABA. The above findings suggest that phosphatidylserine stimulates exogenous GABA uptake into brain GABAergic nerve terminals.
γ-氨基丁酸（GABA）与磷脂酰丝氨酸的超声处理脂质体悬浮液（脂质体包裹的GABA）腹腔注射给大鼠后，可抑制青霉素诱导的脑电图癫痫活动，而GABA本身则无此作用。与注射[14C]GABA相比，腹腔注射与磷脂酰丝氨酸结合的[14C]GABA后5分钟，脑放射性积累显著增加（20.4%）；这种增加在20分钟后仍持续存在。然而，注射脂质体包裹的GABA后5分钟，脑突触体中的放射性积累增加了24.1%，随后在20分钟时增加了43.3%。上述发现表明，磷脂酰丝氨酸可刺激外源性GABA摄取进入脑内GABA能神经末梢。
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