Das A K, Hajra A K
Neuroscience Laboratory, University of Michigan, Ann Arbor 48109.
FEBS Lett. 1988 Jan 25;227(2):187-90. doi: 10.1016/0014-5793(88)80895-0.
When 1-O-heptadecyl-rac-glycerol was fed (20 mg/g of food) to 19-day-old rats for 10 days, a high incorporation of the heptadecyl group into the 1-O-alk-1'-enyl group of ethanolamine plasmalogens of all tissues was observed. For example, 62% of the alkenyl groups from liver plasmalogen was of the 17:0 variety. The analogous values for other tissues were 62% in kidney, 57% in lung, 57% in heart, 50% in intestine, 43% in erythrocytes, 25% in testis and 8% in brain. The corresponding figures in the control rats (fed normal rat chow) were only 2-3% of 17:0 for all tissues. Available evidence indicates that dietary 1-O-heptadecyl-sn-glycerol is utilized to form tissue plasmalogens without the cleavage of the ether bond. The relevance of these results to the possible dietary ether lipid therapy of patients suffering from congenital ether lipid deficiency is discussed.
给19日龄大鼠喂食1-O-十七烷基-外消旋甘油（20毫克/克食物），持续10天，结果观察到所有组织乙醇胺缩醛磷脂的1-O-烷-1'-烯基中十七烷基的掺入率很高。例如，肝脏缩醛磷脂中62%的烯基为17:0类型。其他组织的相应数值分别为：肾脏62%、肺57%、心脏57%、肠道50%、红细胞43%、睾丸25%、大脑8%。对照大鼠（喂食正常大鼠饲料）所有组织中相应的17:0数值仅为2%-3%。现有证据表明，膳食中的1-O-十七烷基-sn-甘油可用于形成组织缩醛磷脂，而无需醚键断裂。本文讨论了这些结果与先天性醚脂缺乏症患者可能的膳食醚脂治疗的相关性。
