Lobo R A, Nguyen H N, Eggena P, Brenner P F
Department of Obstetrics and Gynecology, University of Southern California School of Medicine, Los Angeles.
Fertil Steril. 1988 Feb;49(2):234-8. doi: 10.1016/s0015-0282(16)59708-8.
In order to determine the relative potency of equilin sulfate (EqS), a major constituent of conjugated equine estrogens, 15 women received oral doses of EqS (0.15, 0.31, and 0.625 mg) for 25 days. Doses of 0.31 and 0.625 mg significantly stimulated hepatic globulins. This stimulatory effect ranged from being 1.5 to 8 times greater than the effects of comparable doses of estrone sulfate and conjugated equine estrogens. A significant stimulation in high-density lipoprotein-cholesterol occurred with as little as 0.15 mg of EqS. Elevations in the high-density lipoprotein/low-density lipoprotein-cholesterol ratio occurred with EqS, which resulted in an approximately 4-fold greater response than that achieved with comparable doses of conjugated equine estrogens. The fasting urinary calcium/creatinine ratio was only significantly lowered with 0.625 mg of EqS and was less potent than conjugated equine estrogens in this regard. It is concluded that EqS is a potent estrogen that contributes significantly to the hepatic stimulatory effects of conjugated equine estrogens. These data also provide support for the suggestion that there may be a dissociation in potency between estrogenic effects on liver and bone.
为了确定结合马雌激素的主要成分硫酸马萘雌酮（EqS）的相对效价，15名女性口服EqS（0.15、0.31和0.625毫克），持续25天。0.31毫克和0.625毫克的剂量显著刺激了肝脏球蛋白。这种刺激作用比同等剂量的硫酸雌酮和结合马雌激素的作用大1.5至8倍。低至0.15毫克的EqS就能显著刺激高密度脂蛋白胆固醇。EqS使高密度脂蛋白/低密度脂蛋白胆固醇比值升高，与同等剂量的结合马雌激素相比，其反应大约大4倍。仅0.625毫克的EqS能显著降低空腹尿钙/肌酐比值，在这方面其效力低于结合马雌激素。结论是EqS是一种强效雌激素，对结合马雌激素的肝脏刺激作用有显著贡献。这些数据也支持了关于雌激素对肝脏和骨骼的作用效价可能存在解离的观点。
