Garewal H S, Sampliner R, Gerner E, Steinbronn K, Alberts D, Kendall D
Department of Internal Medicine, Tucson Veterans Administration Medical Center, Arizona.
Gastroenterology. 1988 Mar;94(3):819-21. doi: 10.1016/0016-5085(88)90259-4.
Ornithine decarboxylase activity is known to be increased in certain premalignant conditions. We determined the activity of this enzyme in mucosal biopsy specimens from 15 patients with Barrett's esophagus. Ornithine decarboxylase was greater in Barrett's mucosa than in squamous esophageal or gastric mucosa. In Barrett's mucosa from 4 patients with dysplasia, the enzyme activity was greater than in 11 patients without dysplasia (1.6 +/- 0.35 vs. 0.19 +/- 0.08 U/mg protein; p less than 0.005). Increased ornithine decarboxylase activity in biopsy specimens of Barrett's mucosa may represent a marker for dysplasia.
已知鸟氨酸脱羧酶活性在某些癌前病变中会升高。我们测定了15例巴雷特食管患者黏膜活检标本中该酶的活性。巴雷特黏膜中的鸟氨酸脱羧酶活性高于鳞状食管黏膜或胃黏膜。在4例发育异常的巴雷特黏膜患者中，酶活性高于11例无发育异常的患者（1.6±0.35对0.19±0.08 U/mg蛋白；p<0.005）。巴雷特黏膜活检标本中鸟氨酸脱羧酶活性增加可能是发育异常的一个标志物。
