大剂量顺铂与5-氟尿嘧啶持续输注治疗转移性及复发性宫颈鳞状细胞癌的评估

Evaluation of bolus cis-platinum and continuous 5-fluorouracil infusion for metastatic and recurrent squamous cell carcinoma of the cervix.

作者信息

Rotmensch J, Senekjian E K, Javaheri G, Herbst A L

机构信息

Department of Obstetrics and Gynecology, University of Chicago, Chicago Lying-In Hospital, Illinois 60637.

出版信息

Gynecol Oncol. 1988 Jan;29(1):76-81. doi: 10.1016/0090-8258(88)90149-7.

DOI:10.1016/0090-8258(88)90149-7

PMID:3338666

Abstract

The combination of cis-platinum and 5-fluorouracil has been reported to act synergistically with improved response rates in squamous cell carcinomas of the head and neck. The activity of bolus cis-platinum and continuous infusion of 5-fluorouracil in 24 patients with recurrent and metastatic squamous cell carcinoma of the cervix was evaluated. Twelve patients were stage I, 3 were stage II, 5 were stage III, and 4 were stage IV cervical carcinomas. Among the 24 patients, there were 4 complete and 8 partial responses (50%). The overall median response was 24 weeks. The overall cumulative survival was 55% at 40 weeks and 40% at 1 year after beginning this regimen. Complications included 4 patients who developed leukopenia, 3 thrombocytopenia, 11 stomatitis, 14 nephrotoxicity, 4 peripheral neuropathy, and 6 ototoxicity. The combination of cis-platinum and continuous infusion of 5-fluorouracil appears to have useful activity in patients with recurrent or metastatic squamous cell carcinoma of the cervix.

摘要

据报道，顺铂和5-氟尿嘧啶联合使用对头颈部鳞状细胞癌具有协同作用，可提高缓解率。对24例复发性和转移性宫颈鳞状细胞癌患者进行了大剂量顺铂和持续输注5-氟尿嘧啶的活性评估。12例患者为I期，3例为II期，5例为III期，4例为IV期宫颈癌。24例患者中，有4例完全缓解，8例部分缓解（50%）。总体中位缓解期为24周。开始该治疗方案后，40周时总体累积生存率为55%，1年时为40%。并发症包括4例发生白细胞减少的患者、3例血小板减少、11例口腔炎、14例肾毒性、4例周围神经病变和6例耳毒性。顺铂和持续输注5-氟尿嘧啶联合使用对复发性或转移性宫颈鳞状细胞癌患者似乎具有有效的活性。