Kucera H, Weghaupt K
Department of Gynecological Radiotherapy, University of Vienna, Austria.
Gynecol Oncol. 1988 Feb;29(2):158-67. doi: 10.1016/0090-8258(88)90210-7.
The results of treatment in the department of 607 patients with invasive squamous cell carcinoma of the vulva between 1952 and 1980 is described and analyzed. The absolute 5-year cure rate in these patients was 60.3%. Particular attention was given to lymph node status (TNM system) in the analysis of the last 141 patients treated. The absolute 5-year survival rate was 67% for the N0-N1 patients and 43% for the N2-N3 patients. Patients were treated uniformly by means of electrosurgical operation and postactinic irradiation of the inguinal lymph nodes. Operative lymphadenectomy was performed only in 5% of cases when the diameter of inguinal lymph nodes was greater than 2 cm. This simple surgical technique, in combination with irradiation of inguinal lymph nodes, gives excellent results and avoids the complications associated with inguinofemoral lymphadenectomy. Owing to its combination of electrosurgical operation of the vulva and irradiation of the inguinal regions as a standard procedure, the treatment involves extremely low strain on the patient and is almost free of complications. This seems to be particularly important as the results of our treatment are not less satisfactory than those of more aggressive procedures.
本文描述并分析了1952年至1980年间该科室607例浸润性外阴鳞状细胞癌患者的治疗结果。这些患者的5年绝对治愈率为60.3%。在分析最后141例接受治疗的患者时，特别关注了淋巴结状态（TNM系统）。N0 - N1期患者的5年绝对生存率为67%，N2 - N3期患者为43%。患者均采用电外科手术及腹股沟淋巴结术后放疗进行统一治疗。仅在5%的病例中，当腹股沟淋巴结直径大于2 cm时才进行手术淋巴结清扫。这种简单的手术技术与腹股沟淋巴结放疗相结合，取得了优异的效果，并避免了与腹股沟股淋巴结清扫相关的并发症。由于以外阴电外科手术和腹股沟区放疗相结合作为标准治疗程序，该治疗对患者造成的负担极小，且几乎没有并发症。鉴于我们的治疗结果并不比更积极的治疗方法差，这一点似乎尤为重要。
