Department of Transfusion Medicine, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok, Thailand.
Department of Medicine, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok, Thailand.
Asian Pac J Allergy Immunol. 2024 Mar;42(1):77-80. doi: 10.12932/AP-130520-0842.
Natural killer (NK) cells have been implicated in the immune response against multiple myeloma (MM) cells. Killer cell immunoglobulin-like receptors (KIRs) regulate NK cell activity by recognizing specific human leukocyte antigen (HLA) class I as ligands.
To investigate the association of KIR genes and ligands with MM in the Thai population.
KIR gene polymorphisms and their HLA ligands were investigated in 66 Thai patients with MM and 200 healthy controls.
The frequencies of KIR3DL1 and 2DS4 were significantly lower in myeloma patients than in controls (P = 0.02). The frequencies of KIR3DL1, 2DS4, 2DL1 with C2, and 3DL1 with Bw4 were significantly higher in the patients achieving > very good partial response (VGPR) than those achieving ≤ VGPR after treatment with bortezomib (P = 0.009, 0.009, 0.01, and 0.02, respectively).
This study suggests the association of KIR genes with the protection against MM and the association of inhibitory KIR and ligands with the response to treatment in MM.
自然杀伤 (NK) 细胞被认为参与了对多发性骨髓瘤 (MM) 细胞的免疫反应。杀伤细胞免疫球蛋白样受体 (KIR) 通过识别特定的人类白细胞抗原 (HLA) Ⅰ类作为配体来调节 NK 细胞的活性。
研究 KIR 基因及其配体与泰国人群中 MM 的关联。
在 66 例泰国 MM 患者和 200 例健康对照者中，研究了 KIR 基因多态性及其 HLA 配体。
与对照组相比，骨髓瘤患者 KIR3DL1 和 2DS4 的频率明显降低 (P = 0.02)。与治疗后获得≤非常好部分缓解 (VGPR) 的患者相比，获得>VGPR 的患者 KIR3DL1、2DS4、2DL1 与 C2 和 3DL1 与 Bw4 的频率明显更高 (P = 0.009、0.009、0.01 和 0.02)。
本研究提示 KIR 基因与 MM 的保护作用有关，抑制性 KIR 和配体与 MM 治疗反应有关。
