Hospital da Luz, Aveiro, Portugal.
Instituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa, Lisboa, Portugal.
Clin Hemorheol Microcirc. 2021;77(4):395-410. doi: 10.3233/CH-200956.
Calcium, vitamin D and insulin resistance are linked to osteoporosis and cardiovascular disease in menopause.
Determine if hemorheological parameters related to blood viscosity in microcirculation are linked to calcium metabolism and insulin resistance in menopause.
25-Hydroxyvitamin D (25(OH)D)), 1, 25-dihydroxyvitamin D3 (1, 25(OH)2D), parathyroid hormone, ionized calcium, glucose, insulin and hemoglobin A1c were measured in blood from 43 volunteers. Red blood cells (RBC) aggregation, RBC deformability and whole blood viscosity were also performed.
25(OH)D showed a positive correlation with RBC deformability 0.60 Pa. Subjects with 25(OH)D≤29.00 ng/mL had lower RBC deformability 0.60 Pa, and higher RBC aggregation and higher HOMA-IR. Ionized calcium showed a negative correlation with RBC aggregation. Subjects with ionized calcium ≤1.24 mmol/L showed higher RBC aggregation. There was a positive correlation between HOMA-IR and RBC aggregation and HOMA-IR showed a negative correlation with RBC deformability 0.30 Pa. Subjects with HOMA-IR <1.80 showed lower RBC aggregation and higher RBC deformability at 0.30 Pa, 0.60 Pa, 1.20 Pa, 3.0 Pa and 6.0 Pa.
Low 25(OH)D, low ionized calcium and high HOMA-IR are related to impaired hemorheology in menopause. RBC aggregation and deformability can be used as biomarkers of calcium metabolism and insulin resistance in menopause.
钙、维生素 D 和胰岛素抵抗与绝经后骨质疏松症和心血管疾病有关。
确定与微循环血液黏度相关的血液流变学参数是否与绝经后钙代谢和胰岛素抵抗有关。
检测 43 名志愿者血液中的 25-羟维生素 D（25(OH)D）、1,25-二羟维生素 D3（1,25(OH)2D）、甲状旁腺激素、离子钙、血糖、胰岛素和糖化血红蛋白。还进行了红细胞（RBC）聚集、RBC 变形性和全血黏度的检测。
25(OH)D 与 RBC 变形性 0.60 Pa 呈正相关。25(OH)D≤29.00 ng/mL 的受试者 RBC 变形性 0.60 Pa 较低，RBC 聚集和 HOMA-IR 较高。离子钙与 RBC 聚集呈负相关。离子钙≤1.24 mmol/L 的受试者 RBC 聚集较高。HOMA-IR 与 RBC 聚集呈正相关，与 RBC 变形性 0.30 Pa 呈负相关。HOMA-IR<1.80 的受试者 RBC 聚集较低，0.30 Pa、0.60 Pa、1.20 Pa、3.0 Pa 和 6.0 Pa 的 RBC 变形性较高。
低 25(OH)D、低离子钙和高 HOMA-IR 与绝经后血液流变学异常有关。RBC 聚集和变形性可作为绝经后钙代谢和胰岛素抵抗的生物标志物。
