Department of Metabolism and Nutrition, Institute of Food Science, Technology and Nutrition (ICTAN-CSIC), José Antonio Novais 10, 28040, Madrid, Spain.
Department of Food Technology, Veterinary Faculty, Complutense University, Avda/Puerta de Hierro, s/n, 28040, Madrid, Spain.
Eur J Nutr. 2021 Aug;60(5):2671-2681. doi: 10.1007/s00394-020-02451-6. Epub 2021 Jan 2.
The aim of this study was to determine whether grape polyphenols have a "second-meal effect", modulating glucose and lipid elevations in the postprandial period after two successive meals in subjects with obesity.
A randomized, double-blind, placebo-controlled, acute clinical trial was conducted. Twenty-five obese subjects (BMI = ≥ 30 and < 40 kg/m) were randomly divided into two groups. At an initial visit, blood was collected in a fasting state and the subjects received breakfast and 46 g of either grape powder (equivalent to 252 g fresh grapes) or placebo, both solved in water. Lunch was provided 5 h later and then blood was collected after 0, 30, 60, 120, 180, 240, 300, 330, 360, and 420 min since arrival. Two weeks later, at a second visit, the subjects received the other powder. The following were determined: glucose, insulin, triglycerides, uric acid, blood count, hemoglobin, viscosity, antioxidant capacity, and satiety perception.
Postprandial increases were observed as expected in, for example, glucose and triglycerides after breakfast and lunch. The grape powder supplementation did not cause any significant modification compared to placebo, in these parameters; nor did it significantly modify plasma antioxidant capacity in the 6 h postprandial period.
Single grape powder supplementation did not modify postprandial responses in obese subjects, probably because the polyphenol dose was insufficient to induce such an effect. The result of a combination of grape with other polyphenol-rich products or chronic supplementation with grape powder on postprandial responses remains to be elucidated.
www.clinicaltrials.gov , NCT03741218.
本研究旨在确定葡萄多酚是否具有“第二餐效应”，即在连续两餐后，是否能调节肥胖受试者餐后血糖和血脂升高。
进行了一项随机、双盲、安慰剂对照、急性临床试验。25 名肥胖受试者（BMI≥30 且<40 kg/m²）被随机分为两组。在初次就诊时，受试者空腹采集血液，并接受早餐和 46 克葡萄粉（相当于 252 克新鲜葡萄）或安慰剂，均溶于水。5 小时后提供午餐，然后在 0、30、60、120、180、240、300、330、360 和 420 分钟后采集血液。2 周后，在第二次就诊时，受试者接受另一种粉末。测定以下指标：血糖、胰岛素、甘油三酯、尿酸、血常规、血红蛋白、粘度、抗氧化能力和饱腹感。
早餐和午餐后，葡萄糖和甘油三酯等指标的餐后增加如预期那样出现。与安慰剂相比，葡萄粉补充剂并未对这些参数产生任何显著影响；也未在餐后 6 小时内显著改变血浆抗氧化能力。
单次葡萄粉补充并未改变肥胖受试者的餐后反应，可能是因为多酚剂量不足以产生这种效果。葡萄与其他富含多酚的产品联合使用或长期补充葡萄粉对餐后反应的影响仍有待阐明。
www.clinicaltrials.gov ，NCT03741218。
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