Private Practice, Clínica VSP-Vivian Simões Pires, Porto Alegre, Brazil.
School of Medicine, Pontifícia Universidade Católica do Rio Grande do Sul, Porto Alegre, Brazil.
J Cosmet Dermatol. 2021 Sep;20(9):2750-2752. doi: 10.1111/jocd.13930. Epub 2021 Jan 19.
Hyaluronic acid filler treatments are a very popular nonsurgical procedure worldwide, most wanted to create a more attractive profile and correct facial aging. Since its usage has expanded, more complications have been seen.
To report a probably new adverse effect related to injectable fillers.
A 38-year-old white woman who underwent hyaluronic acid filling in the periorbital area and presented twelve months after with two symmetrically yellowish plaque lesions on the lower eyelids, with no edema or nodules.
The lesion appeared to be xanthelasma, in a patient with no history of hyperlipidemia. Histological analysis showed unspecific findings with rare histiocytes present in the papillary dermis. The patient was treated with hyaluronidase infiltration in both lower eyelid areas as an attempt to minimize the appearance of the lesions, with a satisfactory response.
As hyaluronic acid fillings are becoming more popular, all physicians have to be aware of its complications. The xanthelasma-like reaction is probably a new adverse effect related to injectable fillers and it is important to be alert to this possibility.
透明质酸填充剂治疗是一种非常流行的非手术治疗方法，在全球范围内，大多数人希望通过这种方法来塑造更具吸引力的容貌并纠正面部衰老。随着其应用范围的扩大，出现了更多的并发症。
报告一种可能与注射用填充物有关的新的不良反应。
一位 38 岁的白人女性，在眶周区域接受了透明质酸填充，一年后出现了两个对称的下眼睑黄色斑块病变，无水肿或结节。
病变表现为睑黄瘤，患者无高血脂病史。组织学分析显示，在乳头真皮中仅存在少量组织细胞，无特异性发现。对两个下眼睑区域进行了透明质酸酶浸润治疗，试图减轻病变的外观，取得了满意的效果。
随着透明质酸填充剂的日益普及，所有医生都必须了解其并发症。这种类似睑黄瘤的反应可能是一种与注射用填充物有关的新的不良反应，对此应保持警惕。
