Zhang Hui-Zhi, Wang Su-Ying
Department of Pathology, Ningbo Diagnostic Pathology Center, Ningbo, Zhejiang, China.
Department of Pathology, Ningbo Diagnostic Pathology Center, Ningbo, Zhejiang, China.
Curr Probl Cancer. 2021 Jun;45(3):100689. doi: 10.1016/j.currproblcancer.2020.100689. Epub 2020 Dec 29.
Alpha-fetoprotein (AFP) is a useful tumor marker for hepatocellular carcinomas and yolk sac tumors. Rare extrahepatic visceral malignancies may be associated with AFP production and those exhibiting a hepatoid differentiation by morphology and immunohistochemical are classified as hepatoid adenocarcinoma. Renal cell carcinoma (RCC) producing AFP is a rare entity. To date, only one case of AFP-producing Xp11 translocation RCC has been reported. We reported another case of Xp11 translocation RCC, in which the tumor cells displayed strong immunostaining for AFP, HepPar1, and GPC-3. Additionally, the other published cases are reviewed.
甲胎蛋白（AFP）是肝细胞癌和卵黄囊瘤的一种有用的肿瘤标志物。罕见的肝外内脏恶性肿瘤可能与AFP产生有关，那些在形态学和免疫组织化学上表现出肝样分化的肿瘤被归类为肝样腺癌。产生AFP的肾细胞癌（RCC）是一种罕见的实体。迄今为止，仅报道过1例产生AFP的Xp11易位性RCC。我们报告了另一例Xp11易位性RCC，其中肿瘤细胞对AFP、HepPar1和GPC-3呈强免疫染色。此外，还对其他已发表的病例进行了回顾。
