Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Weigla 12, 53-114, Wrocław, Poland.
Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Weigla 12, 53-114, Wrocław, Poland.
Curr Opin Biotechnol. 2021 Apr;68:186-192. doi: 10.1016/j.copbio.2020.11.011. Epub 2020 Dec 31.
Antibodies specific to phage virions have been observed many times, both in animals and in humans. Phages induce the T-dependent type of immune response, which is fundamental for immunological memory and long retention of abilities to recognize and respond to foreign epitopes. Experimental models have shown that phage-specific antibodies can be devastating for a phage in vivo. Observations from phage treatment in humans demonstrate however that antibodies do not necessarily hinder phage therapy. Controlling effective doses may help in controlling the immune response to phage and to create 'therapeutic windows' for the phage. Phage therapy design may also benefit from understanding phage antigenicity and predicting possible cross-reactions between antibodies specific to different phages.
噬菌体衣壳特异性抗体在动物和人类中已被多次观察到。噬菌体诱导 T 依赖性免疫应答，这对于免疫记忆和长期保留识别和应对外来表位的能力至关重要。实验模型表明，噬菌体特异性抗体可能对体内噬菌体具有破坏性。然而，从噬菌体治疗在人类中的观察结果表明，抗体不一定会阻碍噬菌体治疗。控制有效剂量可能有助于控制对噬菌体的免疫反应，并为噬菌体创造“治疗窗口”。了解噬菌体抗原性和预测针对不同噬菌体的抗体之间可能发生的交叉反应，也可能使噬菌体治疗设计受益。
