噬菌体疗法可能是攻克儿童持续性肺部细菌感染的关键。
Phage therapy could be key to conquering persistent bacterial lung infections in children.
作者信息
Sithu Shein Aye Mya, Hongsing Parichart, Khatib Aisha, Phattharapornjaroen Phatthranit, Miyanaga Kazuhiko, Cui Longzhu, Shibuya Kenji, Amarasiri Mohan, Monk Peter N, Kicic Anthony, Chatsuwan Tanittha, Higgins Paul G, Abe Shuichi, Wannigama Dhammika Leshan
机构信息
Department of Microbiology, Faculty of Medicine, Chulalongkorn University, King Chulalongkorn Memorial Hospital, Thai Red Cross Society, Bangkok, Thailand.
Center of Excellence in Antimicrobial Resistance and Stewardship Research, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.
出版信息
NPJ Antimicrob Resist. 2024 Oct 10;2(1):31. doi: 10.1038/s44259-024-00045-4.
Persistent bacterial lung infections in children lead to significant morbidity and mortality due to antibiotic resistance. In this paper, we describe how phage therapy has shown remarkable efficacy in preclinical and clinical studies, demonstrating significant therapeutic benefits through various administration routes. Ongoing trials are evaluating its safety and effectiveness against different pathogens. Advancing phage therapy through systematic studies and international collaboration could provide a viable alternative to traditional antibiotics for persistent infections.
由于抗生素耐药性，儿童持续性细菌性肺部感染会导致严重的发病率和死亡率。在本文中，我们描述了噬菌体疗法如何在临床前和临床研究中显示出显著疗效，通过各种给药途径证明了显著的治疗益处。正在进行的试验正在评估其对不同病原体的安全性和有效性。通过系统研究和国际合作推进噬菌体疗法，可为持续性感染提供一种可行的替代传统抗生素的方法。
Zotero 插件