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单外科医生行球部尿道狭窄切除吻合术的经验:手术和患者报告结局分析。

Single-surgeon experience of excision and primary anastomosis for bulbar urethral stricture: analysis of surgical and patient-reported outcomes.

机构信息

Department of Urology, National Defense Medical College, 3-2 Namiki, Tokorozawa, Saitama, 359-8513, Japan.

Department of Urology, Nishisaitama-Chuo National Hospital, Saitama, Japan.

出版信息

World J Urol. 2021 Aug;39(8):3063-3069. doi: 10.1007/s00345-020-03539-8. Epub 2021 Jan 3.

DOI:10.1007/s00345-020-03539-8
PMID:33388917
Abstract

PURPOSE

To report our experience with excision and primary anastomosis (EPA) for bulbar urethral stricture.

METHODS

Patients who underwent EPA for bulbar stricture between 2012 and 2019 were retrospectively analyzed (n = 308). Successful urethroplasty was defined as the absence of the need for additional treatment. For follow-up, uroflowmetry was performed and the patients completed the validated Urethral Stricture Surgery Patient-reported Outcome Measure and Sexual Health Inventory for Men (SHIM) questionnaires before (baseline) and 6 months after EPA. Overall patient satisfaction after urethroplasty was also evaluated.

RESULTS

Urethroplasty was successful in 97.1% of patients (n = 299) with a median follow-up of 37 months. A total of 215 patients (69.8%) completed the questionnaires at 6 months postoperatively. The mean maximum flow rate, lower urinary tract symptom (LUTS)-total score, Peeling's picture score, LUTS-specific quality of life, and EuroQol-visual analog scale scores improved significantly from 7.7 ml/s, 11.6, 3.3, 2.4, and 58.0 at baseline to 24.1 ml/s, 2.7, 1.9, 0.4, and 82.1 postoperatively (p < 0.0001 for all comparisons). However, five-point or greater deterioration in the SHIM score was found in 41 patients (19.1%). Regarding patient satisfaction, 98.6% of patients (212/215) were "satisfied" (32.6%) or "very satisfied" (66.0%) with the outcome. A low postoperative LUTS-total score and Peeling's picture score were independent predictors of a "very satisfied" patient (p = 0.001 and p = 0.01, respectively).

CONCLUSIONS

EPA had a high success rate and was associated with significant benefits in both subjective and objective outcomes. Contrarily, a high incidence of postoperative erectile dysfunction was observed.

摘要

目的

报告我们采用尿道端端吻合术(EPA)治疗球部尿道狭窄的经验。

方法

回顾性分析了 2012 年至 2019 年间接受 EPA 治疗的球部狭窄患者(n=308)。成功的尿道成形术定义为无需进一步治疗。随访时,进行尿流率检查,患者在 EPA 术前(基线)和术后 6 个月时完成经过验证的尿道狭窄手术患者报告结局测量量表和男性性功能健康问卷(SHIM)。还评估了尿道成形术后患者的总体满意度。

结果

97.1%(n=299)的患者的尿道成形术成功,中位随访时间为 37 个月。共有 215 例患者(69.8%)在术后 6 个月完成了问卷调查。最大尿流率、下尿路症状(LUTS)总分、Peeling 评分、LUTS 特异性生活质量和 EuroQol 视觉模拟量表评分从基线时的 7.7ml/s、11.6、3.3、2.4 和 58.0 显著改善至术后 24.1ml/s、2.7、1.9、0.4 和 82.1(所有比较均 p<0.0001)。然而,41 例患者(19.1%)的 SHIM 评分下降了 5 分或更多。关于患者满意度,215 例患者中有 98.6%(212/215)对结果“满意”(32.6%)或“非常满意”(66.0%)。术后 LUTS 总分和 Peeling 评分较低是患者“非常满意”的独立预测因素(p=0.001 和 p=0.01)。

结论

EPA 成功率高,与主观和客观结果均有显著改善相关。然而,术后勃起功能障碍的发生率较高。

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