神经肽Y对离体兔虹膜开大肌的作用。
Effects of neuropeptide Y on the isolated rabbit iris dilator muscle.
作者信息
Piccone M, Littzi J, Krupin T, Stone R A, Davis M, Wax M B
机构信息
Department of Ophthalmology, Scheie Eye Institute, University of Pennsylvania School of Medicine, Philadelphia 19104.
出版信息
Invest Ophthalmol Vis Sci. 1988 Feb;29(2):330-2.
The effects of neuropeptide Y (NPY) were studied on an in vitro preparation of rabbit iris dilator muscle. NPY by itself (10(-11) M to 10(-6) M) had no effect on the resting tension or on the maximal electrically-induced response (MER) of the dilator. Phenylephrine (10(-9) M to 10(-4) M) caused a dose-dependent contraction of the dilator muscle (7.8% to 40.6% of the MER). The addition of NPY 10(-6) M enhanced the phenylephrine-induced muscle contraction (8.8% to 76.8% of the MER) without altering the EC50 value (5 X 10(-6) M) of the phenylephrine dose-response curve. These findings support a modulatory role for NPY on the iris dilator muscle.
研究了神经肽Y（NPY）对兔虹膜开大肌体外制备物的影响。单独的NPY（10⁻¹¹M至10⁻⁶M）对开大肌的静息张力或最大电诱导反应（MER）没有影响。去氧肾上腺素（10⁻⁹M至10⁻⁴M）引起开大肌剂量依赖性收缩（MER的7.8%至40.6%）。添加10⁻⁶M的NPY可增强去氧肾上腺素诱导的肌肉收缩（MER的8.8%至76.8%），而不改变去氧肾上腺素剂量反应曲线的EC50值（5×10⁻⁶M）。这些发现支持NPY对虹膜开大肌具有调节作用。
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