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[着色芽生菌病和暗色丝孢霉病的治疗]

[Treatment of chromoblastomycosis and phaeohyphomycosis].

作者信息

Dobiáš Radim, Havlíček Vladimír

机构信息

Laboratory of Clinical Mycology, Institute of Health based in Ostrava, Department of Bacteriology and Mycology, Czech Republic, e-mail:

出版信息

Klin Mikrobiol Infekc Lek. 2020 Jun;26(2):62-68.

Abstract

Cases of chromoblastomycosis are frequent in certain parts of the world, especially in some developing countries. Clinical manifestations of chromoblastomycosis are typical. To a certain extent, pathogens causing chromoblastomycosis overlap with those causing phaeohyphomycosis. Although cases of phaeohyphomycosis are not very common, they may end fatally. Therefore early management of these life-threatening infections is rather important. Targeted antifungal therapy and surgery are effective in combating these infections. Recently, several triazole antifungals such as posaconazole and isavuconazole have been available to treat even the most severe cases. Prevention of the infection should be aimed at reducing the risk of subcutaneous trauma, particularly in persons in contact with potential sources of infection such as wood materials important from endemic areas.

摘要

着色芽生菌病病例在世界某些地区很常见,尤其是在一些发展中国家。着色芽生菌病的临床表现很典型。在一定程度上,引起着色芽生菌病的病原体与引起暗色丝孢霉病的病原体有重叠。虽然暗色丝孢霉病病例不太常见,但可能会致命。因此,早期处理这些危及生命的感染相当重要。针对性抗真菌治疗和手术对对抗这些感染有效。最近,几种三唑类抗真菌药如泊沙康唑和艾沙康唑已可用于治疗甚至最严重的病例。感染的预防应旨在降低皮下创伤的风险,特别是在接触潜在感染源(如来自流行地区的重要木材材料)的人群中。

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