可成药抗衰剂的发现
The Discovery of Druggable Anti-aging Agents.
作者信息
Yalcin Gulperi, Lee Cheol-Koo
机构信息
Department of Biotechnology, College of Life Sciences and Biotechnology, Korea University, Seoul, Korea.
出版信息
Ann Geriatr Med Res. 2020 Dec;24(4):232-242. doi: 10.4235/agmr.20.0092. Epub 2020 Dec 29.
Abstract
Caloric restriction (CR) has been shown to extend the lifespan of many species. Research to identify compounds that imitate the results of CR has shown extensions of both lifespan and healthspan via different mechanisms. For example, mechanistic target of rapamycin (mTOR) inhibitors such as rapamycin, phenols, and flavonoids show antioxidant characteristics, while spermidine induces autophagy. Herein, we summarize research progress and proposed mechanisms for the most well-known compounds showing lifespan-extending potential for anti-aging characteristics.
摘要
热量限制（CR）已被证明能延长多种物种的寿命。旨在鉴定能模拟热量限制效果的化合物的研究表明，通过不同机制可实现寿命和健康寿命的延长。例如，雷帕霉素、酚类和黄酮类等雷帕霉素的机制性靶点（mTOR）抑制剂具有抗氧化特性，而亚精胺可诱导自噬。在此，我们总结了最著名的具有抗衰老特性且有延长寿命潜力的化合物的研究进展及提出的作用机制。
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