土耳其人群中肢端肥大症患者的合并症患病率及相关因素。
Prevalence of comorbidities and associated factors in acromegaly patients in the Turkish population.
机构信息
Department of Internal Medicine, Division of Endocrinology and Metabolism, Faculty of Medicine, Necmettin Erbakan University, Konya, Turkey
出版信息
Turk J Med Sci. 2021 Jun 28;51(3):1146-1152. doi: 10.3906/sag-2007-243.
BACKGROUND/AIM: The presence of comorbidities in patients with acromegaly causes an increase in morbidity and/or mortality and a decrease in quality of life. In this study, we aimed to investigate the demographic, clinical and laboratory features, prevalence of acro- megaly-related comorbidities, and factors associated with these comorbidities in patients with acromegaly.
MATERIALS AND METHODS
In the study, 96 patients who were followed up with the diagnosis of acromegaly were included. Clinical, labo- ratory and imaging features, and accompanying comorbidities of the patients were recorded from the patient files.
RESULTS
Of the patients included in the study, 63 (65.6%) were female and 33 (34.4%) were male. The mean age of diagnosis was 42.61± 12.08, and the mean follow-up period was 9.97 ± 7.26 years. Median insulin-like growth factor 1 level was 238.16 ng/mL (30.5–820), median growth hormone level was 2.05 ug/L (0.1–29.4). A total of 60 (62.5%) of the patients were in the well-controlled group, and 36 (37.5%) had active disease at the time of inclusion. Diabetes mellitus (DM) was detected in 30 (31.3%) patients, prediabetes in 19 (28.8%) patients, hypertriglyceridemia in 38 (42.2%) patients, hypertension (HT) in 41 (42.7%) patients, cardiovascular disease in 5 (5.2%) patients, malignancy in 9 (9.4%) patients, obstructive sleep apnea syndrome in 8 (8.3%) patients, carpal tunnel syndrome in 11 (11.5%) patients, arthropathy in 5 (5.2%) patients, hearing loss in 7 (7.3%) patients, thyroid nodule in 56 (67.5%) patients, thyroid cancer in 4 (4.2%) patients, colonic polyp in 19 (38.8%) patients.
CONCLUSION
In this study, we revealed that the most common comorbidities in acromegaly patients in the Turkish population are thyroid nodules, low high-density lipoprotein (HDL cholesterol (HDL-C) level, hypertriglyceridemia, HT, colonic polyps, DM, and prediabetes, and female sex and age at diagnosis are the most important factors associated with comorbidities.
背景/目的：肢端肥大症患者合并症的存在会导致发病率和/或死亡率增加，以及生活质量下降。在这项研究中，我们旨在调查肢端肥大症患者的人口统计学、临床和实验室特征、肢端肥大症相关合并症的患病率，以及与这些合并症相关的因素。
材料和方法
本研究共纳入 96 例诊断为肢端肥大症的患者。从患者病历中记录患者的临床、实验室和影像学特征以及伴随的合并症。
结果
在本研究中，63 例（65.6%）为女性，33 例（34.4%）为男性。诊断时的平均年龄为 42.61±12.08 岁，平均随访时间为 9.97±7.26 年。中位胰岛素样生长因子 1 水平为 238.16ng/mL（30.5-820），中位生长激素水平为 2.05ug/L（0.1-29.4）。共有 60 例（62.5%）患者处于良好控制组，36 例（37.5%）在纳入时患有活动性疾病。30 例（31.3%）患者检测出糖尿病（DM），19 例（28.8%）患者存在糖尿病前期，38 例（42.2%）患者存在高三酰甘油血症，41 例（42.7%）患者存在高血压（HT），5 例（5.2%）患者存在心血管疾病，9 例（9.4%）患者存在恶性肿瘤，8 例（8.3%）患者存在阻塞性睡眠呼吸暂停综合征，11 例（11.5%）患者存在腕管综合征，5 例（5.2%）患者存在关节病，7 例（7.3%）患者存在听力损失，56 例（67.5%）患者存在甲状腺结节，4 例（4.2%）患者存在甲状腺癌，19 例（38.8%）患者存在结肠息肉。
结论
在这项研究中，我们揭示了土耳其肢端肥大症患者最常见的合并症是甲状腺结节、低高密度脂蛋白（HDL）胆固醇（HDL-C）水平、高三酰甘油血症、HT、结肠息肉、糖尿病、糖尿病前期，以及女性和诊断时的年龄是与合并症相关的最重要因素。
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