Department of Cardiology, Domingo Braile Institute, Rua Luiz Vaz de Camoes, São José do Rio Preto-SP, Brazil.
Curr Cardiol Rev. 2021;17(5):e190721189769. doi: 10.2174/1573403X16999201231203405.
Coronary artery disease (CAD) represents approximately 390 thousand deaths per year in Brazil and is associated, among other predictors, with the use of anabolic and androgenic steroids (AAS).
To analyze a clinical case of a patient who suffered AMI after abuse of AAS. A systematic literature review has been carried out to physiologically analyze the main factors that can lead to AMI with the use of these hormones.
The EVR patient, 41 years old, denies any comorbidities or use of medications. He has been admitted to the emergency room due to typical angina-precordial pain in tightness associated with eventual back pain and paresthesia of both upper limbs, after intense physical effort at the gym, without improvement at rest, and with partial improvement after first care at the health unit. The patient was hypertensive in an emergency bed after the occurrence of ST elevation. The patient alleges the use of anabolic steroids for one month. The patient presented with obstructive atherosclerotic coronary artery disease with total occlusion of the anterior descending artery. Systematic review: A total of 89 clinical studies have been compared and submitted to eligibility analysis, with 50 studies selected, according to the PRISMA rules.
Long-term consumption of AAS may cause pathological changes, however, AAS can increase protein synthesis, muscle growth, and erythropoiesis.
Abuse of AAS has a toxic cardiovascular effect, which significantly increases the incidence of cardiovascular diseases.
在巴西，每年约有 39 万人死于冠心病（CAD），与其他预测因素一样，它与使用合成代谢和雄激素类固醇（AAS）有关。
分析一名滥用 AAS 后发生急性心肌梗死（AMI）的患者的临床病例。进行了系统的文献回顾，以从生理学角度分析使用这些激素导致 AMI 的主要因素。
EVR 患者，41 岁，否认有任何合并症或使用药物。他因在健身房进行剧烈体力活动后出现典型的前胸痛伴紧束感，并伴有最终背痛和双上肢感觉异常而被紧急送入急诊室，休息时疼痛无缓解，在健康单位接受初步治疗后有所缓解。患者在 ST 段抬高发生后紧急病床出现高血压。患者声称在一个月内使用了合成代谢类固醇。患者表现为阻塞性动脉粥样硬化性冠状动脉疾病，前降支完全闭塞。系统评价：共比较了 89 项临床研究，并根据 PRISMA 规则进行了合格性分析，选择了 50 项研究。
长期使用 AAS 可能导致病理性变化，然而，AAS 可以增加蛋白质合成、肌肉生长和红细胞生成。
滥用 AAS 具有毒性心血管作用，显著增加了心血管疾病的发病率。
