Department of Hepatopancreatobiliary Surgery, Third Xiangya Hospital, Central South University, Changsha 410013, Hunan, China.
Int J Med Sci. 2021 Jan 1;18(2):534-545. doi: 10.7150/ijms.51618. eCollection 2021.
Acute pancreatitis (AP) is a leading cause of gastrointestinal-related hospital admissions with significant morbidity and mortality. Although the underlying pathophysiology of AP is rather complex, which greatly limits the treatment options, more and more studies have revealed that infiltrating immune cells play a critical role in the pathogenesis of AP and determine disease severity. Thus, immunomodulatory therapy targeting immune cells and related inflammatory mediators is expected to be a novel treatment modality for AP which may improve the prognosis of patients. Cells of the innate immune system, including macrophages, neutrophils, dendritic cells, and mast cells, represent the majority of infiltrating cells during AP. In this review, an overview of different populations of innate immune cells and their role during AP will be discussed, with a special focus on neutrophils and macrophages.
急性胰腺炎（AP）是导致胃肠道相关住院的主要原因，具有显著的发病率和死亡率。尽管 AP 的潜在病理生理学相当复杂，这极大地限制了治疗选择，但越来越多的研究表明，浸润免疫细胞在 AP 的发病机制中起着关键作用，并决定疾病的严重程度。因此，针对免疫细胞和相关炎症介质的免疫调节治疗有望成为 AP 的一种新的治疗方法，可能改善患者的预后。先天免疫系统的细胞，包括巨噬细胞、中性粒细胞、树突状细胞和肥大细胞，是 AP 期间浸润细胞的主要组成部分。在这篇综述中，将讨论不同群体的先天免疫细胞及其在 AP 中的作用，特别关注中性粒细胞和巨噬细胞。
