Altundal Yücel, Cifter Fulya, Mu Guangwei, Lee James, Wu Elisa J, Yeung Vincent, Katz Alan
Medical Physics, Flushing Radiation Oncology Services, Flushing, USA.
Medical Physics, Precess Medical, Short Hills, USA.
Cureus. 2020 Nov 23;12(11):e11660. doi: 10.7759/cureus.11660.
Purpose The aim of this study is to investigate the feasibility of prostate stereotactic body radiation therapy treatment with a newly developed Varian Halcyon 2.0 machine by comparing radiotherapy plans with previously delivered CyberKnife G4 plans created with the previous version of CyberKnife Treatment Planning System Multiplan 4.6.1. Methods Fifteen previously treated prostate stereotactic body radiation therapy treatment CyberKnife plans were re-planned retrospectively according to the Radiation Therapy Oncology Group 0938 protocol on a Halcyon 2.0 machine with a prescription of 3625 cGy in five fractions. Results All re-plans on a Halcyon 2.0 were able to meet the Radiation Therapy Oncology Group 0938 protocol goals and constraints. The re-plans decreased the maximum dose to skin and urethra, mean doses to the bladder and rectum, and also improve the conformity index and the Planning Target Volume coverage. However, D1cc to the rectum, D1cc and D10% to the bladder increased with no statistically significant differences (p > 0.05) with the re-plans. Conclusion The Halcyon 2.0 can generate stereotactic body radiation therapy treatment prostate plans created based on the Radiation Therapy Oncology Group 0938 protocol by delivering adequate coverage to the target while sparing healthy tissues.
目的 本研究的目的是通过将放射治疗计划与先前使用CyberKnife治疗计划系统Multiplan 4.6.1创建并已实施的CyberKnife G4计划进行比较，研究使用新开发的瓦里安Halcyon 2.0机器进行前列腺立体定向体部放射治疗的可行性。方法 根据放射治疗肿瘤学组0938协议，在Halcyon 2.0机器上对15个先前接受过治疗的前列腺立体定向体部放射治疗的CyberKnife计划进行回顾性重新规划，处方剂量为3625 cGy，分五次照射。结果 在Halcyon 2.0上进行的所有重新规划均能够满足放射治疗肿瘤学组0938协议的目标和限制。重新规划降低了皮肤和尿道的最大剂量、膀胱和直肠的平均剂量，还提高了适形指数和计划靶区覆盖率。然而，直肠的D1cc、膀胱的D1cc和D10%有所增加，重新规划后差异无统计学意义（p>0.05）。结论 Halcyon 2.0可以根据放射治疗肿瘤学组0938协议生成前列腺立体定向体部放射治疗计划，在保护健康组织的同时为靶区提供足够的覆盖。
