Zimmerman B, Chambers C, Forsyth S
Department of Pediatrics, Hospital for Sick Children, Toronto, Ontario, Canada.
J Allergy Clin Immunol. 1988 Jan;81(1):71-7. doi: 10.1016/0091-6749(88)90222-9.
The relationship between allergy and asthma in infants and preschool children was investigated. One hundred nine children, median age 2 1/2 years, were examined immunologically by quantitation of serum IgE, RAST testing to 13 allergens, and culture of peripheral blood lymphocytes for spontaneous IgE formation. We examined a cross-section of infants and toddlers to determine whether the severity of asthma is associated with allergy as has been reported in older children with asthma. We identified a group of highly atopic infants and preschool children who have serum IgE at least 10 times the mean + 1 SE for age, multiple positive RASTs with early formation of IgE to inhalant antigens, and circulating B cells that spontaneously form IgE when these are cultured in vitro. Such highly atopic infants and preschool children were statistically more likely to have chronic asthma requiring multiple continuous medication compared to the rest of the population (p less than 0.01).
对婴儿和学龄前儿童的过敏与哮喘之间的关系进行了调查。109名儿童，中位年龄为2.5岁，通过血清IgE定量、针对13种变应原的RAST检测以及外周血淋巴细胞培养以检测自发IgE形成进行了免疫学检查。我们对婴儿和幼儿进行了横断面研究，以确定哮喘的严重程度是否与过敏相关，就像在大龄哮喘儿童中所报道的那样。我们确定了一组高度特应性的婴儿和学龄前儿童，他们的血清IgE至少是同年龄组均值+1个标准差的10倍，对吸入性抗原的IgE早期形成有多个阳性RAST结果，并且其循环B细胞在体外培养时会自发形成IgE。与其他人群相比，这类高度特应性的婴儿和学龄前儿童在统计学上更有可能患有需要多种持续药物治疗的慢性哮喘（p<0.01）。
