Qi Xin-Zheng, Wang Min, Zhang Bo, Nie Mao-Dan, Ma Xiao-Ying, Wang Hui-Zhi, Wang Xiao-Hong, Cheng Cheng-Kung, Zhang Min
Beijing Advanced Innovation Centre for Biomedical Engineering, School of Biological Science and Medical Engineering, Beihang University, Beijing, China.
Department of Orthopaedics, Xinqiao Hospital, Army Medical University (Third Military Medical University), Chongqing, China.
Front Bioeng Biotechnol. 2020 Dec 18;8:610763. doi: 10.3389/fbioe.2020.610763. eCollection 2020.
The aim of this study was to evaluate the association between the morphology of the proximal tibiofibular joint (PTFJ) and the presence of knee osteoarthritis (OA). Twenty-eight OA subjects and 30 healthy subjects were enrolled in this study. A 3D model of the lower limb of each subject was constructed from CT scans and used to measure the characteristics of the PTFJ, including the shape of the articular facets, articular surface area, joint inclination, relative articular height, and joint declination. The association between the characteristics of the PTFJ and presence of knee OA was assessed using binomial logistic regression analysis. There was a significant difference between the OA and healthy groups in terms of the inclination ( = 0.028) and declination ( = 0.020) of the PTFJ and relative articular height ( = 0.011). A greater inclination angle (OR: 1.463, 95% CI: 1.124-1.582, = 0.021), greater declination angle (OR: 1.832, 95% CI: 1.691-2.187, = 0.009), and lower relative articular height (OR: 0.951, 95% CI: 0.826-0.992, = 0.008) were found to be associated with an increased likelihood of knee OA being present. The results of this study suggest that abnormal PTFJ morphology is associated with the presence of knee OA.
本研究的目的是评估胫腓近侧关节（PTFJ）形态与膝关节骨关节炎（OA）存在之间的关联。本研究纳入了28名OA受试者和30名健康受试者。根据CT扫描构建每个受试者下肢的3D模型，并用于测量PTFJ的特征，包括关节面形状、关节表面积、关节倾斜度、相对关节高度和关节偏斜度。使用二项逻辑回归分析评估PTFJ特征与膝关节OA存在之间的关联。在PTFJ的倾斜度（P = 0.028）、偏斜度（P = 0.020）和相对关节高度（P = 0.011）方面，OA组和健康组之间存在显著差异。发现更大的倾斜角（OR：1.463，95%CI：1.124 - 1.582，P = 0.021）、更大的偏斜角（OR：1.832，95%CI：1.691 - 2.187，P = 0.009）和更低的相对关节高度（OR：0.951，95%CI：0.826 - 0.992，P = 0.008）与膝关节OA存在的可能性增加相关。本研究结果表明，PTFJ形态异常与膝关节OA的存在有关。
