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Elevated factor V activity and antigen levels in patients with Covid-19 are related to disease severity and 30-day mortality.

作者信息

von Meijenfeldt Fien A, Havervall Sebastian, Adelmeijer Jelle, Lundström Annika, Magnusson Maria, Mackman Nigel, Thalin Charlotte, Lisman Ton

机构信息

Surgical Research Laboratory, Department of Surgery, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.

Division of Internal Medicine, Department of Clinical Sciences, Karolinska Institutet, Danderyd Hospital, Stockholm, Sweden.

出版信息

Am J Hematol. 2021 Apr 1;96(4):E98-E100. doi: 10.1002/ajh.26085. Epub 2021 Jan 22.

DOI:10.1002/ajh.26085
PMID:33393103
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7986218/
Abstract
摘要

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本文引用的文献

1
Prothrombotic changes in patients with COVID-19 are associated with disease severity and mortality.新冠肺炎患者的血栓前状态改变与疾病严重程度和死亡率相关。
Res Pract Thromb Haemost. 2020 Dec 6;5(1):132-141. doi: 10.1002/rth2.12462. eCollection 2021 Jan.
2
Imbalance between procoagulant factors and natural coagulation inhibitors contributes to hypercoagulability in the critically ill COVID-19 patient: clinical implications.促凝因子与天然抗凝抑制剂失衡导致危重症 COVID-19 患者高凝状态：临床意义。
Eur Rev Med Pharmacol Sci. 2020 Sep;24(17):9161-9168. doi: 10.26355/eurrev_202009_22866.
3
Marked factor V activity elevation in severe COVID-19 is associated with venous thromboembolism.严重 COVID-19 中标记的因子 V 活性升高与静脉血栓栓塞相关。
Am J Hematol. 2020 Dec;95(12):1522-1530. doi: 10.1002/ajh.25979. Epub 2020 Sep 18.
4
Platelet activation and platelet-monocyte aggregate formation trigger tissue factor expression in patients with severe COVID-19.血小板激活和血小板-单核细胞聚集体形成可触发重症 COVID-19 患者组织因子表达。
Blood. 2020 Sep 10;136(11):1330-1341. doi: 10.1182/blood.2020007252.
5
Unique in vivo modifications of coagulation factor V produce a physically and functionally distinct platelet-derived cofactor: characterization of purified platelet-derived factor V/Va.凝血因子V独特的体内修饰产生了一种在物理和功能上都截然不同的血小板衍生辅因子：纯化的血小板衍生因子V/Va的特性
J Biol Chem. 2004 Jan 23;279(4):2383-93. doi: 10.1074/jbc.M308600200. Epub 2003 Oct 31.