Bratisl Lek Listy. 2021;122(1):45-48. doi: 10.4149/BLL_2021_005.
To analyse the effect of systemic inflammatory status in patients with primary open-angle glaucoma (POAG) and primary angle-closure glaucoma (PACG) by calculating platelet-to-lymphocyte ratio (PLR) and neutrophil-to-lymphocyte ratio (NLR).
This retrospective case-control study included 200 patients with POAG, 22 patients with PACG and 100 healthy subjects. The participants' white-blood-cell, lymphocyte, neutrophil, and platelet counts were recorded from previous blood assays. NLR and PLR were calculated manually. Results were compared among the groups.
Both the POAG and PACG groups had higher platelet counts and PLR values than the control group (p=0.001 and p=0.001; respectively). The difference in NLR between POAG, PACG and control groups was not statistically significant (p=0.076). The POAG group had higher NLR values than the control (p=0.035).
Both the POAG and the PACG groups exhibited higher platelet and PLR levels than the control. These results indicate a potential role of systemic inflammation in the pathogenesis of POAG and PACG (Tab. 4, Fig. 1, Ref. 35).
通过计算血小板与淋巴细胞比值（PLR）和中性粒细胞与淋巴细胞比值（NLR），分析原发性开角型青光眼（POAG）和原发性闭角型青光眼（PACG）患者全身炎症状态的影响。
本回顾性病例对照研究纳入了 200 名 POAG 患者、22 名 PACG 患者和 100 名健康对照者。从之前的血液检测中记录参与者的白细胞、淋巴细胞、中性粒细胞和血小板计数。手动计算 NLR 和 PLR。比较各组间的结果。
POAG 组和 PACG 组的血小板计数和 PLR 值均高于对照组（p=0.001 和 p=0.001）。POAG、PACG 和对照组之间 NLR 的差异无统计学意义（p=0.076）。POAG 组的 NLR 值高于对照组（p=0.035）。
POAG 组和 PACG 组的血小板和 PLR 水平均高于对照组。这些结果表明全身炎症可能在 POAG 和 PACG 的发病机制中起作用（表 4，图 1，参考文献 35）。
