Correlation of miR-600 with WT1 expression and its potential clinical significance in breast cancer.

The study aimed to explore miR-600 and expression and its potential clinical significance in breast cancer. The expression of miR-600 and in tumor and non-tumor adjacent tissues in 45 breast cancer patients as well as serum level of miR-600 in these patients and 45 healthy group were analyzed. The expression level of miR-600 in tumor tissue and serum of patients was significantly lower than non-tumor adjacent tissues and serum of controls, respectively, while mRNA and protein levels were higher in tumor tissues compared with non-tumor adjacent tissues. The miR-600 expression was correlated with lymph node metastasis and clinical stage. The miR-600 acts as tumor suppressor and a diagnostic and prognostic biomarker in breast cancer patients.