Department of Orthopedics, Rheumatology and Traumatology, School of Medical Science-University of Campinas, Brazil.
Autoimmunity Lab- School of Medical Science- University of Campinas, Brazil.
Expert Rev Clin Immunol. 2021 Feb;17(2):143-153. doi: 10.1080/1744666X.2020.1865156. Epub 2021 Jan 22.
: Systemic lupus erythematosus (SLE) is a chronic autoimmune disorder, characterized by a relapsing and remitting pattern of disease activity in majority of the patients. : This narrative review provides an overview of flare definition, major flare mimics, and the burden of flares in SLE. The authors highlight epidemiology and disease-related risk factor for flares and discuss strategies to reduce flares in SLE. Articles were selected from Pubmed searches conducted between June 2020 and September 2020. : Prolonged clinical remission is observed in approximately 20% of SLE patients flare over the course of the disease. Studies have shown that low disease activity is a good target in SLE, with similar risk of flares, mortality, and quality of life when compared to patients in remission. Clinical and immunological features have shown inconsistent results to identify patients at risk of flares in different cohorts. Cytokine, in serum and urine, has shown promising results to predict flares. However to be useful in clinical practice, they have to be simple, easy, and cost-effective. Future efforts in this direction will allow a more personalized treatment plan for SLE patients, reducing the burden associated with flares.
系统性红斑狼疮 (SLE) 是一种慢性自身免疫性疾病，大多数患者的疾病活动呈现复发缓解模式。本文叙述性综述概述了狼疮发作的定义、主要的狼疮发作模拟以及 SLE 发作的负担。作者强调了狼疮发作的流行病学和与疾病相关的危险因素，并讨论了减少 SLE 发作的策略。文章选自 2020 年 6 月至 2020 年 9 月期间在 Pubmed 上进行的检索。在疾病过程中，约 20%的 SLE 患者会出现长时间的临床缓解。研究表明，低疾病活动度是 SLE 的一个很好的治疗目标，与缓解期患者相比，其发作、死亡率和生活质量的风险相似。临床和免疫特征在不同队列中显示出不一致的结果，以确定处于发作风险中的患者。细胞因子在血清和尿液中的表现显示出有希望的预测结果。然而，为了在临床实践中有用，它们必须简单、易用且具有成本效益。未来在这方面的努力将为 SLE 患者制定更个性化的治疗计划，减少与发作相关的负担。
