College of Chemistry and Chemical Engineering, Inner Mongolia University of Science and Technology, Baotou 014000, China.
Dalton Trans. 2021 Feb 2;50(4):1300-1306. doi: 10.1039/d0dt03906c.
Bacillus anthracis is an extremely dangerous bacterium that is associated with high morbidity and mortality. 2,6-Pyridine dicarboxylic acid (DPA) is a major biomarker of Bacillus anthracis, and it is of great significance to be able to detect DPA in a rapid, efficient, and sensitive way. Herein, a 3D network metal-organic framework (Tb-MOF) with excellent thermal and water stability was synthesized. Tb-MOF could be used to selectively detect DPA via green fluorescence recovery with a fluorescence intensity enhancement factor of 103. In addition, due to the high detection sensitivity (a detection limit of 2.4 μM) and excellent anti-interference abilities, Tb-MOF was less affected by environmental factors when compared with a "turn-off"-response luminescence sensor; it can be employed as a promising "turn-on" luminescence sensor for DPA in the future. Finally, quantum calculations showed that a large energy difference appeared between the 5D4 level of Tb3+ and the first excited triplet energy level of H2-DHBDC2-, which was the reason that the complex did not show characteristic Tb3+ emission.
炭疽芽孢杆菌是一种极其危险的细菌，与高发病率和死亡率有关。2,6-吡啶二甲酸（DPA）是炭疽芽孢杆菌的主要生物标志物，能够快速、高效、灵敏地检测 DPA 具有重要意义。本文合成了一种具有优异热稳定性和水稳定性的三维网络金属有机骨架（Tb-MOF）。Tb-MOF 可以通过绿色荧光恢复来选择性地检测 DPA，荧光强度增强因子为 103。此外，由于具有较高的检测灵敏度（检测限为 2.4 μM）和出色的抗干扰能力，与“关断”型发光传感器相比，Tb-MOF 受环境因素的影响较小；它有望成为未来 DPA 的一种有前途的“开”式发光传感器。最后，量子计算表明，Tb3+的 5D4 能级和 H2-DHBDC2-的第一激发三重态能级之间出现了较大的能量差，这就是该配合物没有表现出特征 Tb3+发射的原因。
