Martenson J A, Buskirk S J, Ilstrup D M, Banks P M, Evans R G, Colgan J P, Earle J D
Division of Radiation Oncology, Mayo Clinic, Rochester, MN 55905.
J Clin Oncol. 1988 Feb;6(2):297-302. doi: 10.1200/JCO.1988.6.2.297.
Patterns of failure were analyzed in 30 patients with testicular non-Hodgkin's lymphoma: 16 had stage IE disease, ten had stage IIE, and four had stage IV. After orchiectomy, two of the 16 patients with stage IE disease received no additional therapy, one received multiagent chemotherapy, and 13 received pelvic and para-aortic radiation. Twelve patients with stage IE disease had progression, and the median time to progression was 12 months. Of the 14 patients with extratesticular involvement (stage IIE or IV), one (stage IV) received no treatment after orchiectomy, three (stage IIE) received para-aortic and pelvic radiation, and ten (seven stage IIE and three stage IV) received multiagent chemotherapy with or without radiation. Eight of the patients with stage IIE or IV disease had progression, and the median time to progression was 11 months. Widespread extranodal progression was observed in 17 of the 20 patients who had progression. The tendency of testicular lymphoma for early systemic progression suggests a need for multiagent chemotherapy in initial management.
对30例睾丸非霍奇金淋巴瘤患者的失败模式进行了分析：16例为IE期疾病，10例为IIE期，4例为IV期。睾丸切除术后，16例IE期疾病患者中有2例未接受额外治疗，1例接受了多药化疗，13例接受了盆腔和腹主动脉旁放疗。12例IE期疾病患者病情进展，进展的中位时间为12个月。在14例有睾丸外受累的患者（IIE期或IV期）中，1例（IV期）睾丸切除术后未接受治疗，3例（IIE期）接受了腹主动脉旁和盆腔放疗，10例（7例IIE期和3例IV期）接受了多药化疗，部分联合或未联合放疗。8例IIE期或IV期疾病患者病情进展，进展中位时间为11个月。在20例病情进展的患者中，有17例观察到广泛的结外进展。睾丸淋巴瘤早期全身进展的趋势表明在初始治疗中需要多药化疗。
