Department of Clinical Pharmacology, School of Pharmacy, China Medical University, No.77 Puhe Road, Shenyang North New Area, Shenyang, Liaoning, 110122, People's Republic of China.
Mol Biol Rep. 2021 Jan;48(1):975-981. doi: 10.1007/s11033-020-06065-3. Epub 2021 Jan 4.
Calcium-sensing receptor (CaSR) is widely involved in the cell proliferation, differentiation, migration, adhesion and apoptosis, which can affect the vascular remodeling in the humanbody. The main ligand of CaSR is extracellular Ca. CaSR has the physiological significance in Ca homeostasis. Pulmonary vascular remodeling is one of the main histopathological changes of pulmonary hypertension (PH). The abnormal proliferation of pulmonary artery smooth muscle cells (PASMCs) results in the pulmonary vascular remodeling. CaSR is an important regulator of [Ca]. [Ca] is the main cause of the excessive pulmonary vascular remodeling in patients with PH. In this review, it was conclued that the structure of CaSR was prone to explore the devolopment or the treatment of PH. It was found that the regulation of CaSR with some miRNA could inhibit the proliferation of PASMCs, and that CaSR could affect the occurrence of autophagy in PH. Therefore, CaSR would become a new therapeutic target to PH.
钙敏感受体（CaSR）广泛参与细胞增殖、分化、迁移、黏附和凋亡，影响人体血管重构。CaSR 的主要配体是细胞外 Ca。CaSR 在钙稳态中具有生理意义。肺血管重构是肺动脉高压（PH）的主要组织病理学变化之一。肺动脉平滑肌细胞（PASMCs）的异常增殖导致肺血管重构。CaSR 是 [Ca]的重要调节剂。[Ca]是 PH 患者肺血管过度重构的主要原因。本综述认为，CaSR 的结构易于探索 PH 的发展或治疗。研究发现，某些 miRNA 对 CaSR 的调节可抑制 PASMCs 的增殖，CaSR 可影响 PH 中的自噬发生。因此，CaSR 将成为 PH 的一个新的治疗靶点。
