School of Respiratory Therapy, College of Medicine, Taipei Medical University, Taipei, Taiwan; Division of Pulmonary Medicine, Department of Internal Medicine, Wan Fang Hospital, Taipei Medical University, Taipei, Taiwan.
School of Respiratory Therapy, College of Medicine, Taipei Medical University, Taipei, Taiwan.
Ecotoxicol Environ Saf. 2021 Jan 15;208:111618. doi: 10.1016/j.ecoenv.2020.111618. Epub 2020 Nov 10.
Air pollution has been recognized to be a risk factor for lung cancer. The objective of this study was to investigate the effects of air pollution on heavy metal alterations in the pleural effusion of lung cancer patients. Pleural effusion was collected from patients with lung cancer and congestive heart failure (CHF). One-year average levels of particulate matter with an aerodynamic diameter of < 10 µm (PM), PM, NO, and SO were linked to the exposure of these subjects. Traffic-related metals, included Al, Fe, Cu, Zn, and Pb, were determined in the pleural effusion. Logistic regression models were used to examine their associations. There were 63 lung cancer patients and 31 CHF patients enrolled in the current study. We found that PM, PM, and NO were negatively correlated with Al in the pleural effusion, whereas PM was positively correlated with Zn in the pleural effusion. Increases in 1 μg/m of PM and 1 ng/mL of Zn were associated with lung cancer (adjusted OR=2.394, 95% CI= 1.446-3.964 for PM; adjusted OR=1.003, 95% CI=1.000-1.005 for Zn). Increases in PM and Zn in the pleural effusion increased the risk of malignant pleural effusion in lung cancer patients (adjusted OR=1.517; 95% CI=1.082-2.127 for PM; adjusted OR=1.002, 95% CI=1.000-1.005 for Zn). Furthermore, we observed that adenocarcinomas increased in association with a 1-μg/m increase in PM (crude OR=1.683; 95% CI=1.006-2.817) in lung cancer patients. In conclusion, PM exposure and the possible resultant Zn in the pleural effusion associated with the development of malignant pleural effusion in lung cancer.
空气污染已被确认为肺癌的一个风险因素。本研究旨在探讨空气污染对肺癌患者胸腔积液中重金属变化的影响。采集了肺癌和充血性心力衰竭（CHF）患者的胸腔积液。将这些受试者的暴露与 PM10、PM2.5、NO 和 SO 的年平均水平相关联。在胸腔积液中测定了与交通相关的金属，包括 Al、Fe、Cu、Zn 和 Pb。使用逻辑回归模型来检验它们之间的关联。本研究共纳入了 63 例肺癌患者和 31 例 CHF 患者。我们发现，胸腔积液中 PM10、PM2.5 和 NO 与 Al 呈负相关，而 PM2.5 与胸腔积液中的 Zn 呈正相关。PM10 和 Zn 每增加 1μg/m3 和 1ng/mL，与肺癌相关（调整后的 OR=2.394，95%CI=1.446-3.964 对于 PM10；调整后的 OR=1.003，95%CI=1.000-1.005 对于 Zn）。胸腔积液中 PM10 和 Zn 的增加增加了肺癌患者恶性胸腔积液的风险（调整后的 OR=1.517；95%CI=1.082-2.127 对于 PM10；调整后的 OR=1.002，95%CI=1.000-1.005 对于 Zn）。此外，我们观察到在肺癌患者中，PM10 每增加 1μg/m3，腺癌的比例增加（粗 OR=1.683；95%CI=1.006-2.817）。总之，PM 暴露和胸腔积液中可能产生的 Zn 与肺癌恶性胸腔积液的发生有关。
