Chen P, Dean D A
Am J Trop Med Hyg. 1977 Sep;26(5 Pt 1):963-74.
Guinea pigs infected with Schistosoma mansoni were tested for in vitro lymphocyte response to schistosome antigens and nonspecific mitogens at various times after infection. Production of macrophage migration inhibition factor by peritoneal exudate cells in response to cercarial, adult, and egg antigens reached a peak between 4 and 8 weeks post-infection and diminished rapidly thereafter. In contrast, peak blastogenic responses of blood lymphocytes appeared later than 8 weeks for all antigens and persisted until at least the 24th week. Blastogenic responses to concanavalin A and phytohemagglutinin P were not significantly different in normal and infected animals.
对感染曼氏血吸虫的豚鼠在感染后的不同时间进行体外淋巴细胞对血吸虫抗原和非特异性有丝分裂原反应的检测。腹膜渗出细胞对尾蚴、成虫和虫卵抗原产生的巨噬细胞移动抑制因子在感染后4至8周达到峰值，此后迅速下降。相比之下，所有抗原的血淋巴细胞增殖反应峰值出现在8周以后，并持续到至少第24周。正常动物和感染动物对刀豆球蛋白A和植物血凝素P的增殖反应没有显著差异。
