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非心内科科室心肌梗死的治疗与预后

Treatment and Prognosis of Myocardial Infarction Outside Cardiology Departments.

作者信息

Gard Anton, Lindahl Bertil, Hadziosmanovic Nermin, Baron Tomasz

机构信息

Department of Medical Sciences, Cardiology, Uppsala University, 751 85 Uppsala, Sweden.

Uppsala Clinical Research Center, Uppsala University, 751 85 Uppsala, Sweden.

出版信息

J Clin Med. 2020 Dec 30;10(1):106. doi: 10.3390/jcm10010106.

Abstract

AIM

Our aim was to investigate the characteristics, treatment and prognosis of patients with myocardial infarction (MI) treated outside a cardiology department (CD), compared with MI patients treated at a CD.

METHODS

A cohort of 1310 patients diagnosed with MI at eight Swedish hospitals in 2011 were included in this observational study. Patients were followed regarding all-cause mortality until 2018.

RESULTS

A total of 235 patients, exclusively treated outside CDs, were identified. These patients had more non-cardiac comorbidities, were older (mean age 83.7 vs. 73.1 years) and had less often type 1 MIs (33.2% vs. 74.2%), in comparison with the CD patients. Advanced age and an absence of chest pain were the strongest predictors of non-CD care. Only 3.8% of non-CD patients were investigated with coronary angiography and they were also prescribed secondary preventive pharmacological treatments to a lesser degree, with only 32.3% having statin therapy at discharge. The all-cause mortality was higher in non-CD patients, also after adjustment for baseline parameters, both at 30 days (hazard ratio (HR) 2.28; 95% confidence interval (CI) 1.62-3.22), one year (HR 1.82; 95% CI 1.39-2.36) and five years (HR 1.62; 95% CI 1.32-1.98).

CONCLUSIONS

MI treatment outside CDs is associated with an adverse short- and long-term prognosis. An improved use of percutaneous coronary intervention (PCI) and secondary preventive pharmacological treatment might improve the long-term prognosis in these patients.

摘要

目的

我们的目的是研究在心脏病科(CD)以外接受治疗的心肌梗死(MI)患者的特征、治疗及预后,并与在CD接受治疗的MI患者进行比较。

方法

本观察性研究纳入了2011年在瑞典八家医院被诊断为MI的1310例患者。对患者进行全因死亡率随访直至2018年。

结果

共识别出235例仅在CD以外接受治疗的患者。与CD患者相比,这些患者有更多的非心脏合并症,年龄更大(平均年龄83.7岁对73.1岁),1型MI的发生率更低(33.2%对74.2%)。高龄和无胸痛是接受非CD治疗的最强预测因素。仅3.8%的非CD患者接受了冠状动脉造影检查,他们接受二级预防药物治疗的程度也较低,出院时仅32.3%接受他汀类药物治疗。非CD患者的全因死亡率更高,在对基线参数进行调整后也是如此,在30天时(风险比(HR)2.28;95%置信区间(CI)1.62 - 3.22)、1年时(HR 1.82;95% CI 1.39 - 2.36)和5年时(HR 1.62;95% CI 1.32 - 1.98)。

结论

在CD以外进行的MI治疗与不良的短期和长期预后相关。改善经皮冠状动脉介入治疗(PCI)和二级预防药物治疗的应用可能会改善这些患者的长期预后。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/62b9/7795967/ea81f45f9212/jcm-10-00106-g001.jpg

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