Gard Anton, Lindahl Bertil, Hadziosmanovic Nermin, Baron Tomasz
Department of Medical Sciences, Cardiology, Uppsala University, 751 85 Uppsala, Sweden.
Uppsala Clinical Research Center, Uppsala University, 751 85 Uppsala, Sweden.
J Clin Med. 2020 Dec 30;10(1):106. doi: 10.3390/jcm10010106.
Our aim was to investigate the characteristics, treatment and prognosis of patients with myocardial infarction (MI) treated outside a cardiology department (CD), compared with MI patients treated at a CD.
A cohort of 1310 patients diagnosed with MI at eight Swedish hospitals in 2011 were included in this observational study. Patients were followed regarding all-cause mortality until 2018.
A total of 235 patients, exclusively treated outside CDs, were identified. These patients had more non-cardiac comorbidities, were older (mean age 83.7 vs. 73.1 years) and had less often type 1 MIs (33.2% vs. 74.2%), in comparison with the CD patients. Advanced age and an absence of chest pain were the strongest predictors of non-CD care. Only 3.8% of non-CD patients were investigated with coronary angiography and they were also prescribed secondary preventive pharmacological treatments to a lesser degree, with only 32.3% having statin therapy at discharge. The all-cause mortality was higher in non-CD patients, also after adjustment for baseline parameters, both at 30 days (hazard ratio (HR) 2.28; 95% confidence interval (CI) 1.62-3.22), one year (HR 1.82; 95% CI 1.39-2.36) and five years (HR 1.62; 95% CI 1.32-1.98).
MI treatment outside CDs is associated with an adverse short- and long-term prognosis. An improved use of percutaneous coronary intervention (PCI) and secondary preventive pharmacological treatment might improve the long-term prognosis in these patients.
我们的目的是研究在心脏病科(CD)以外接受治疗的心肌梗死(MI)患者的特征、治疗及预后,并与在CD接受治疗的MI患者进行比较。
本观察性研究纳入了2011年在瑞典八家医院被诊断为MI的1310例患者。对患者进行全因死亡率随访直至2018年。
共识别出235例仅在CD以外接受治疗的患者。与CD患者相比,这些患者有更多的非心脏合并症,年龄更大(平均年龄83.7岁对73.1岁),1型MI的发生率更低(33.2%对74.2%)。高龄和无胸痛是接受非CD治疗的最强预测因素。仅3.8%的非CD患者接受了冠状动脉造影检查,他们接受二级预防药物治疗的程度也较低,出院时仅32.3%接受他汀类药物治疗。非CD患者的全因死亡率更高,在对基线参数进行调整后也是如此,在30天时(风险比(HR)2.28;95%置信区间(CI)1.62 - 3.22)、1年时(HR 1.82;95% CI 1.39 - 2.36)和5年时(HR 1.62;95% CI 1.32 - 1.98)。
在CD以外进行的MI治疗与不良的短期和长期预后相关。改善经皮冠状动脉介入治疗(PCI)和二级预防药物治疗的应用可能会改善这些患者的长期预后。