Department of Industrial & Physical Pharmacy, Purdue University, 575 Stadium Mall Drive, West Lafayette, IN 47907, USA.
Integrated Product Development Organization, Innovation Plaza, Dr.Reddy's Laboratories, Hyderabad 500090, India.
Ther Deliv. 2021 Jan;12(1):37-54. doi: 10.4155/tde-2020-0113. Epub 2021 Jan 5.
Polymeric systems made of poly(lactic acid) or poly(lactic-co-glycolic acid) are widely used for long-term delivery of small and large molecules. The advantages of poly(lactic acid)/poly(lactic-co-glycolic acid) systems include biodegradability, safety and a long history of use in US FDA-approved products. However, as drugs delivered by the polymeric systems and their applications become more diverse, the significance of microenvironment change of degrading systems on long-term drug stability and release kinetics has gained renewed attention. In this review, we discuss various issues experienced with acidifying microenvironment of biodegradable polymer systems and approaches to overcome the detrimental effects of polymer degradation on drug stability and release control.
由聚乳酸或聚乳酸-共-羟基乙酸制成的聚合物系统广泛用于小分子和大分子的长期递送。聚乳酸/聚乳酸-共-羟基乙酸系统的优点包括生物降解性、安全性和在美国食品和药物管理局批准的产品中使用的悠久历史。然而，随着聚合物系统递送的药物及其应用变得更加多样化，降解系统的微环境变化对长期药物稳定性和释放动力学的重要性重新引起了人们的关注。在这篇综述中，我们讨论了可生物降解聚合物系统酸化微环境中遇到的各种问题，以及克服聚合物降解对药物稳定性和释放控制的有害影响的方法。
