Zhao Erman, Tang Xiuling, Zhao Minggao, Yang Le
Precision Pharmacy & Drug Development Center, Department of Pharmacy, Tangdu Hospital, Air Force Medical University, Xi'an, 710038, China.
Drug Deliv Transl Res. 2025 Apr 17. doi: 10.1007/s13346-025-01857-1.
Wound healing for various diseases and wounds such as diabetes and burns remains a major biomedical challenge. Conventional monotherapy is ineffective, and the efficacy of drug delivery is limited by the depth of drug penetration. In this study, we develop a novel, multifunctional, dissolvable hyaluronic acid (HA) microneedle patch (MN-LTT). Microneedling is biocompatible and delivers the drug in a painless and non-invasive manner. Lidocaine and thrombin are mixed with HA hydrogel and loaded onto the needle tips of the MN-LTT, which facilitates wound repair by continuously delivering the drug deep into the dermis for rapid analgesia and hemostasis. In addition, the backing layer of the MN-LTT is composed of tetracycline hydrochloride and HA hydrogel, and its excellent antimicrobial properties further accelerate wound healing. In a mouse full-thickness skin wound model, MN-LTT accelerated cell proliferation and granulation tissue growth, reduced inflammatory-factor levels, and restored collagen deposition, resulting in complete wound healing within seven days. Thus, the proposed microneedle delivery system achieved rapid hemostatic, analgesic, and bactericidal effects, providing a safer and more effective strategy for wound healing. These features make the multifunctional HA microneedle patch potentially valuable for clinical applications.
对于糖尿病和烧伤等各种疾病及伤口的愈合而言，仍然是一项重大的生物医学挑战。传统的单一疗法效果不佳，药物递送的功效受药物渗透深度的限制。在本研究中，我们开发了一种新型的、多功能的、可溶解的透明质酸（HA）微针贴片（MN-LTT）。微针疗法具有生物相容性，能够以无痛且非侵入性的方式递送药物。利多卡因和凝血酶与HA水凝胶混合，并加载到MN-LTT的针尖上，通过持续将药物深入递送至真皮层以实现快速镇痛和止血，从而促进伤口修复。此外，MN-LTT的背衬层由盐酸四环素和HA水凝胶组成，其出色的抗菌性能进一步加速伤口愈合。在小鼠全层皮肤伤口模型中，MN-LTT加速了细胞增殖和肉芽组织生长，降低了炎症因子水平，并恢复了胶原蛋白沉积，从而在七天内实现了完全伤口愈合。因此，所提出的微针递送系统实现了快速止血、镇痛和杀菌效果，为伤口愈合提供了一种更安全、更有效的策略。这些特性使得多功能HA微针贴片在临床应用中具有潜在价值。
